One-Pot Synthesis of Some New -Triazole Derivatives and Their Potential Application for Water Decontamination.

A rapid, efficient, and one-pot protocol has been developed for the synthesis of cyclized 2,6-dimethyl-5-substituted-thiazolo[3,2-]--triazoles () through the interaction of 5-methyl-1--triazole-3-thiol () with aliphatic ketones () in refluxing acetic acid in the presence of a catalytic amount of sulfuric acid (AcOH/H) while with aromatic ketones (), a mixture of uncyclized 3-methyl--triazolylthioacetophenone derivatives () and cyclized 6-aryl-2-methyl-thiazolo[3,2-]--triazoles () has been produced. With this catalytic system, inexpensive sulfuric acid was utilized as a catalyst, which prevented the production of poisonous and irritating halo carbonyl compounds. On the other hand, the interaction of -triazole with cyano compounds () afforded the corresponding 6-amino-2-methyl-5-substituted-thiazolo[3,2-]--triazoles ().

Synthesis of Schiff and Mannich bases of new -triazole derivatives and their potential applications for removal of heavy metals from aqueous solution and as antimicrobial agents.

An efficient, simple, and one-pot double Mannich reaction was performed for the synthesis of cyclized 2-methyl-6-substituted-6,7-dihydro-5-triazolo[5,1-]-1,3,5-thiadiazines a reaction of 5-methyl-1-triazole-3-thiol (1) with formaldehyde and primary aliphatic amines in ethanol at room temperature, while with primary aromatic amines, uncyclized 3-methyl-1-((substituted-amino)methyl)-1-triazole-5-thiols were produced. Under Mannich reaction conditions, 4-amino-3-methyl--triazole-5-thiol (8) reacted with formaldehyde only in boiling ethanol or at room temperature to afford 3-methyl-5,6-dihydro--triazolo[3,4-]-1,3,4-thiadiazole without incorporation of secondary amine. Furthermore, after reaction of compound 8 with aromatic aldehydes under different reaction conditions, uncyclized Schiff's bases were produced.