Publications by authors named "Laila Mohamed AlDabal"
Article Synopsis
- * Whole exome sequencing identified rare, harmful variants in 16 immune-related genes in 31% of patients, with a significant number of these variants linked to interferon and toll-like receptor genes.
- * Findings indicate that genetic variations may contribute to severe COVID-19 outcomes, emphasizing the need for genetic research in diverse populations to enhance our understanding of disease genetics.
Article Synopsis
- A study was conducted to analyze the clinical and genetic features of Middle Eastern patients with Multisystem Inflammatory Syndrome in Children (MIS-C), focusing on those of Arab and Asian descent.
- Involving 45 MIS-C patients and 25 healthy controls, researchers used whole exome sequencing to identify genetic variants and correlate them to the symptoms and severity of the illness.
- Findings revealed significant dysregulation of inflammatory markers in MIS-C patients, with common symptoms including mucocutaneous and gastrointestinal issues, cardiac complications, and rare genetic variants found in immune-related genes.
The geographic location and heterogeneous multi-ethnic population of Dubai (United Arab Emirates; UAE) provide a unique setting to explore the global molecular epidemiology of SARS-CoV-2 and relationship between different viral strains and disease severity. We systematically selected (i.e.
View Article and Find Full Text PDFInternational travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, we establish SARS-CoV-2 full genome sequences from the index and early COVID-19 patients in the UAE.
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