Publications by authors named "Laila Letaief"
Tertiary lymphoid structures (TLS) are lymphoid organs present in inflammatory non-lymphoid tissues. Studies have linked TLS to favorable outcomes for patients with cancers or infectious diseases, but the mechanisms underlying their formation are not fully understood. In particular, secondary lymphoid organs innervation raises the question of sympathetic nerve fibers involvement in TLS organogenesis.
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- * This study analyzed 56 NSCLC patients and found that high densities of TLS-B cells correlated with better profiles of CD4 T cells, showing more naïve and activated types while reducing regulatory T cells (Tregs) and immune checkpoints.
- * A larger study involving 538 untreated NSCLC patients indicated that high TLS-B cell density could mitigate negative impacts from high Treg levels, with patients exhibiting both high TLS-B and Treg densities showing the best survival rates, highlighting B cells' crucial role in immune protection.