Ocimum basilicum L. (basil) presents pro-apoptotic activity in an Ehrlich's experimental tumor murine model.

Purpose: This study aimed to evaluate the therapeutic effect of an ethanol extract of Ocimum basilicum L. (EEOb) aerial parts against Ehrlich's experimental tumor (EET) in mice.

Methods: Swiss mice were divided into two groups (control and treated; n = 6).

Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive loss of cognitive functions, and it is the most prevalent type of dementia worldwide, accounting for 60 to 70% of cases. The pathogenesis of AD seems to involve three main factors: deficiency in cholinergic transmission, formation of extracellular deposits of β-amyloid peptide, and accumulation of deposits of a phosphorylated form of the TAU protein. The currently available drugs are prescribed for symptomatic treatment and present adverse effects such as hepatotoxicity, hypertension, and weight loss.

PREVALENCE OF POSTURAL CHANGES IN SCHOOL CHILDREN AND ADOLESCENTS.

Objective: Investigate the prevalence of postural changes and correlate them with body weight and the weight of schoolchildren's backpacks in a school in the city of São João del-Rei-MG. Material and.

Methods: The study is an original type, with a cross-sectional design, where 109 schoolchildren of both sexes and mean age of 13 years were evaluated.

The Effects of Resistance Exercise on the Cardiorespiratory Tissue of Rats with Parkinson's Disease.

Parkinson's Disease (PD) affects the cardiorespiratory system, causing an increase in the left ventricular mass in the heart and respiratory muscle weakness in relation to healthy individuals. The objective of this study was to investigate the effects of progressive resistive physical exercise on the vertical ladder on the histomorphometry of cardiac tissue and respiratory muscles in rats with PD. Seventy male Wistar rats, aged 40 days old, were divided into Parkinson's (PD) and Sham (SH) groups; they were also subdivided into groups that performed progressive resistive physical exercise on the vertical ladder Before Surgery (ExBS), After Surgery (ExAS), and Before and After Surgery (ExBAS).

High Intensity Physical Exercise before the Brain Ischemia Promotes Increase in Brain Injury.

Studies have demonstrated the beneficial effects of light- and moderate-intensity physical exercise on the nervous system of animals with cerebral ischemia. To investigate the effects of two high-intensity physical exercise protocols, standardized for resistance and strength gain, in rats trained before cerebral ischemia induced by Bilateral Common Carotid Artery Occlusion (BCCAO). Forty-eight male Wistar rats were divided into two groups: with ischemia and without ischemia (sham).

Analysis of motor performance and histomorphometry of skeletal muscles of rats exercised after cerebral ischemia.

Introduction: Cerebral ischemia causes muscle atrophy and motor incoordination in animals, impairing motor performance.

Objective: Thus, the objective of the present study was to analyze the motor performance and histomorphometry of the biceps brachii, soleus, and anterior tibialis muscles of rats submitted to a treadmill training program after induction of cerebral ischemia by the transient occlusion of the middle cerebral artery (MCAO).

Materials And Methods: To do so, twenty-four 30-day-old Wistar rats were utilized.

Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights.

Electrical stimulation of the central nervous system is a promising alternative for the treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is most usually carried out as continuous trains of current or voltage pulses fired at rates of 100 Hz or above, since lower frequencies yield controversial results. On the other hand, stimulation frequency should be as low as possible, in order to maximize implant safety and battery efficiency.

INCIDENCE OF POSTURAL CHANGES AND TEMPOROMANDIBULAR DISORDERS IN STUDENTS.

Objective: The aim of this study was to identify the incidence of postural changes and temporomandibular disorders (TMD) in children and adolescents .

Methods: We selected 117 individuals aged 10-18 years from a state school in the Zona da Mata region of Minas Gerais. The students were evaluated in four stages: assessment of body weight and height and calculation of body mass index; posture evaluation using a questionnaire developed by the researchers; application of a questionnaire recommended by the American Academy of Orofacial Pain to assess TMD; and, finally, application of the Fonseca anamnesis questionnaire .