Efficient one-pot, three-component procedure to prepare new α-aminophosphonate and phosphonic acid acyclic nucleosides.

An efficient one-pot three-component Kabachnik-Fields reaction of aldehydes (acyclic nucleosides), amines (or amino acid), and triethyl phosphite proceeded for the synthesis of aminophosphonates using natural phosphate coated with iodine (I@NP) as a catalyst. The novel α-aminophosphonate and phosphonic acid acyclic nucleosides were tested for their anti-HCV and anti-HIV activities. The molecular docking showed that the non-activity of these compounds could be due to the absence of hydrophobic pharmacophores.

One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst.

Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.

A one step synthetic approach to L-pyrimidine nucleosides using natural phosphate coated with potassium iodide as catalyst.

The one-step synthesis of several alpha-L-arabino and beta-L- xylonucleosides was performed in good yields under mild conditions by N-glycosylation of 1-O-acetyl-L-arabino and -xylofuranose using Vorbruggen type reaction conditions with or without Microwave irradiation.