Dual Detection of Procalcitonin and C-reactive Protein with an Up-converting Nanoparticle Based Lateral Flow Assay.

Procalcitonin (PCT) and C-reactive protein (CRP) are significant complementary inflammatory markers, and their simultaneous detection is of substantial value. In this article, a rapid, simple and cost-effective method for the dual quantitative detection of PCT and CRP in serum is discussed. Two UCNPs of similar size and morphology, but with a different emission spectrum, were prepared for the simultaneous detection of PCT and CRP by lateral flow assay (LFA) technology in a direct method.