Publications by authors named "Laiane da Cruz Pena"
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, can range from mild to severe, with significant clinical complications linked to excessive immune responses and high levels of pro-inflammatory cytokines.
- This study investigated two gene variants, rs2494746 and rs1130214, in relation to severe COVID-19 outcomes, analyzing samples from 508 infected individuals to assess cytokine levels and genetic information.
- Findings revealed that the rs2494746-C allele is associated with worse disease outcomes, including increased severity, ICU admissions, and mortality, contributing valuable insights into how genetic factors affect immune responses to COVID-19.
Background: The worst outcomes linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been attributed to the cytokine storm, which contributes significantly to the immunopathogenesis of the disease. The mammalian target of rapamycin (mTOR) pathway is essential for orchestrating innate immune cell defense including cytokine production and is dysregulated in severe Coronavirus Disease 2019 (COVID-19) individuals. The individual genetic background might play a role in the exacerbated immune response.
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