Ciclosporin-induced hypertension is associated with increased sodium transporter of the loop of Henle (NKCC2).

Background: Hypertension induced by cyclosporine is associated with renal sodium and water retention. Using immunoblotting of kidney homogenates, we investigated the regulation of sodium and water transport proteins in a rat model of cyclosporine-induced hypertension.

Methods: Rats were treated with cyclosporine (25 mg/kg/day intraperitoneally) during 7 days.