Publications by authors named "Laia Meseguer Monfort"
Article Synopsis
- Hidradenitis suppurativa (HS) is linked to a higher risk of cardiovascular diseases, but its genetic connection to cardiometabolic diseases is unclear.
- This study, involving over 391,000 participants from the UK Biobank, analyzed the relationship between a polygenic risk score (PRS) for HS and the likelihood of developing coronary artery disease (CAD) and diabetes.
- Results showed that a high PRS for HS was associated with increased odds of CAD (1.09) and diabetes (1.13), indicating a significant genetic correlation between HS and these cardiometabolic outcomes.
Aims: AP30663 is a novel compound under development for pharmacological conversion of atrial fibrillation by targeting the small conductance Ca activated K (K2) channel. The aim of this extension phase 1 study was to test AP30663 at higher single doses compared to the first-in-human trial.
Methods: Sixteen healthy male volunteers were randomized into 2 cohorts: 6- and 8-mg/kg intravenous single-dose administration of AP30663 vs.