Publications by authors named "Lai-Yuan Wang"
Article Synopsis
- * Researchers analyzed the expression of these miRNAs in various organs and blood components of acute myocardial infarction (AMI) pigs and ACS patients, finding that miR-122 primarily comes from the liver, whereas the others are mainly expressed in the heart.
- * Results showed significant changes in miRNA levels in platelets and peripheral blood mononuclear cells, indicating variations in response to acute coronary events, with specific increases noted in ACS and AMI patients compared to
Article Synopsis
- The study investigates the link between genetic variations in the fibrinogen beta-chain (FGB) gene and the risk of acute myocardial infarction (MI) in a Chinese Han population.
- It analyzed three specific polymorphisms and found that individuals with rare alleles are at a reduced risk for MI, particularly highlighting the R448K polymorphism as significant even after considering other environmental factors.
- The results suggest that the A-K-G haplotype (composed of -455A, 448K, 8558G) offers protective effects against MI compared to the common haplotype, indicating a potential genetic defense mechanism.
Background: Hydrogen sulfide (H(2)S) plays an important role in the smooth muscle cell relaxation and thereby participates in the development of hypertension. Cystathionine gamma-lyase is the key enzyme in the endogenous production of H(2)S. Up to now, the reports on the relationship between the polymorphisms of cystathionine gamma-lyase gene (CTH) and essential hypertension (EH) are limited.
View Article and Find Full Text PDFTNNI3K is a new cardiac-specific MAP kinase whose gene is localized to 1p31.1 and that belongs to a tyrosine kinase-like branch in the kinase tree of the human genome. In the present study we investigated the role of TNNI3K in the cardiac myogenesis process and in the repair of ischemic injury.
View Article and Find Full Text PDFIn the present study, a yeast two-hybrid screening system was used to identify the interaction partners of cardiac troponin I-interacting kinase (TNNI3K) that might serve as regulators or targets, and thus in turn to gain some insights on the roles of TNNI3K. After screening the adult heart cDNA library with a bait construct encoding the ANK motif of TNNI3K, antioxidant protein 1 (AOP-1) was isolated. The interaction between TNNI3K and AOP-1 was confirmed by the in vitro binding assay and coexpression experiments in vivo.
View Article and Find Full Text PDFObjective: To study the association of the apolipoprotein B gene polymorphisms with essential hypertension in Northern Chinese Han population.
Methods: XbaI and EcoRI polymorphisms of the apolipoprotein B (APOB) gene were genotyped by polymerase chain reaction (PCR) and restriction fragment-length polymorphism (RFLP) method in 503 unrelated hypertensive patients and 490 healthy controls recruited from international collaborative study of cardiovascular disease in Asia (InterAsia).
Results: The difference in the genotypic distributions could be neglected across the groups.
[A clinical study of hyperhomocysteinemia in rheumatological diseases].
Zhonghua Nei Ke Za Zhi
February 2005
Objective: To analysis plasma homocysteine (Hcy) level and some relative factors in some rheumatological diseases.
Methods: 54 cases with systemic lupus erythematosus (SLE), 48 cases with rheumatoid arthritis (RA), 60 cases with ankylosing spondylitis (AS), 30 cases with undifferentiated spondyloarthropathy (uSpA) and 62 controls were recruited to participate the study. Plasma Hcy, vitamin B(12), folate and the MTHFR gene C677T polymorphism were measured in all patients and controls.