The study aimed to explore how lead exposure during the development phases of rats affects leptin levels in various body fluids and its potential link to cognitive impairment.
Rats were divided into control and lead-exposed groups based on different lead acetate concentrations in their drinking water, with various methods used to measure lead and leptin levels.
Results indicated that lead exposure increased lead content in the rats while significantly reducing leptin levels in plasma and cerebrospinal fluid, suggesting a connection between decreased leptin and cognitive impairments due to lead toxicity.