Publications by authors named "Lai-Peng Yan"
Although various antibacterial strategies have been developed, antibiotic chemotherapy remains the primary clinical treatment for bacterial infections. To address the limitations associated with the traditional antibiotic therapy, like burst drug release, rapid drug clearance, and the emergence of drug resistance, it is highly desirable to develop drug release systems that can realize controlled and sustained drug release to enhance the therapeutic efficacy. Herein, we present a novel drug release system, CIP@SU-102, which shows superior and long-lasting antibacterial activity.
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- Bone metastasis (BM) significantly worsens the prognosis for patients with primary malignant bone neoplasms (PMBNs), with only 4.8% of diagnosed patients having BM at diagnosis.
- Key risk factors for developing BM include tumor location, size, type (notably Ewing sarcoma), and regional lymph node involvement.
- A nomogram created from identified prognostic factors (like tumor type and treatment history) can effectively predict cancer-specific survival for these patients.
Background: Through previous studies and clinical practice, we have found that real-time ultrasound-guided (UG) spinal anesthesia (SA) and traditional landmark-guided (LG) SA each require a different minimum local anesthetic dose (MLAD) of ropivacaine. For this study, we used Dixon's up-and-down sequential method to analyze and compare the MLAD of different ropivacaine concentrations required for the UG and LG SA methods.
Methods: A total of 120 patients undergoing knee surgery were consecutively recruited and randomly divided into four groups (30 patients per group).