Publications by authors named "Lai Hung Wong"
Background & Aims: Current guidelines recommend a 2-step approach for risk stratification in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) or similar second-line tests. This study aimed to examine to prognostic performance of this approach.
Methods: The VCTE-Prognosis Study was a longitudinal study of patients with MASLD who had undergone VCTE examinations at 16 centres from the US, Europe and Asia with subsequent follow-up for clinical events.
Article Synopsis
- Direct-acting antivirals (DAAs) have improved treatment for chronic hepatitis C (HCV), but there is a lack of focus on the risk of liver-related events (LREs) after achieving sustained virological response (SVR), which this study aims to address with the AI-Safe-C score.
- The AI-Safe-C score, developed using data from 913 non-cirrhotic HCV patients, assesses the risk of LREs by considering factors like liver stiffness measurement (LSM), age, and sex, showing high prediction accuracy in validation cohorts from Korea, Hong Kong, and France.
- This score is essential for identifying non-cirrhotic patients at risk of developing LREs
Background And Aim: Hepatocellular carcinoma is one of the commonest cancer in the world. Despite curative resection, recurrence remains the largest challenge. Many risk factors were identified for predicting recurrence, including liver fibrosis and cirrhosis.
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- Non-alcoholic fatty liver disease and alcohol-related liver disease are big problems because many people are affected, so the researchers wanted to see if a test called transient elastography (TE) is a good way to check for liver problems.
- They analyzed information from over 6,000 people to find out if TE is better than other ways to detect liver fibrosis, especially for those at risk due to drinking alcohol.
- The results showed that using TE is a cost-effective option for screening liver fibrosis in primary care, meaning it provides good value for the money spent, especially in Europe.
Impact of Obesity and Alanine Aminotransferase Levels on the Diagnostic Accuracy for Advanced Liver Fibrosis of Noninvasive Tools in Patients With Nonalcoholic Fatty Liver Disease.
Am J Gastroenterol
June 2019
Introduction: Some evidence suggests an interference of obesity and alanine aminotransferase (ALT) levels on the diagnostic accuracy for advanced fibrosis of noninvasive tools such as liver stiffness measurement (LSM) by FibroScan, Fibrosis-4 (FIB-4), and nonalcoholic fatty liver disease fibrosis score (NFS). We assessed whether the diagnostic accuracy of LSM, Fibrosis-4 (FIB-4), and NFS and strategies based on the combination of these tools is affected by obesity and/or ALT levels.
Methods: We analyzed data from 968 patients with a histological diagnosis of nonalcoholic fatty liver disease.
The emerging role of big data in gastroenterology and hepatology.
J Gastroenterol Hepatol
February 2019
Background & Aims: Diabetes is associated with a 2-fold increase in risk of hepatocellular carcinoma (HCC) among patients with chronic hepatitis B virus (HBV) infection. However, we know little about the effect of diabetes on HCC risk after seroclearance of hepatitis B surface antigen (HBsAg). We evaluated the effect of diabetes and glycemic control on HCC development after HBsAg seroclearance in a population-wide study in Hong Kong.
View Article and Find Full Text PDFWe determined the ability of contrast-enhanced ultrasound (CEUS) using perflubutane microbubbles to diagnose liver fibrosis and cirrhosis in rats using histology as the reference standard. Fibrosis was induced by oral administration of carbon tetrachloride to 32 Wistar rats. Features with baseline ultrasound (US) and enhancement level of liver and spleen with CEUS were obtained.
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