Primary leiomyosarcoma of the nipple-areola complex: report of a case and review of literature.

Primary leiomyosarcoma of the nipple-areola complex is extremely rare. Less than ten such cases have been reported in English literature so far. Herein we describe a 52-year-old female presenting with a 1.

Castleman's disease mimicking intrapulmonary malignancy.

Castleman's disease is a rare disorder characterized by noncancerous growth that may develop in lymph node tissues throughout the body. Most often this occurs in the chest and abdomen, and rarely in the peripherals (10% to 15%). In this article we describe a case of asymptomatic intrapulmonary Castleman's disease mimicking pulmonary malignancy (hyaline-vascular type) in a 42-year-old man who underwent curative surgery.

Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess.

Adiponectin, an adipocyte-derived hormone, possesses insulin-sensitizing, antiinflammatory, and antiatherogenic properties. We hypothesized that hypoadiponectinemia was present in acromegaly, as in other conditions with increased insulin resistance and cardiovascular risk. Using an in-house RIA, serum adiponectin was determined in 35 patients with active acromegaly and 35 age-, sex-, and body mass index-matched healthy controls.

Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.

Growth hormone (GH) is an important regulator of adiposity and systemic energy metabolism. Here, we have investigated the effects of GH on production of adiponectin, an anti-diabetic and anti-atherogenic hormone secreted exclusively from adipocytes. Analysis using real time quantitative PCR revealed that GH significantly increased adiponectin gene expression in a dose-dependent manner.

Cytomegalovirus ischemic colitis of a diabetic renal transplant recipient.

We report a diabetic renal transplant recipient with cytomegalovirus (CMV) disease who presented with tarry stool diarrhea because of multiple colonic ulcerations. Histopathology revealed diffuse colonic ulcers following a process of ischemic vasculitis. The colonic ulcers disappeared dramatically after 2 wk of intravenous ganciclovir therapy.

Pulmonary granulomatosis associated with insoluble fillers in a heroin addict.

We report a case of acute respiratory distress syndrome (ARDS) and pulmonary granulomatosis after intravenous injection of heroin. This 46-year-old male had a 2-year history of heroin addiction. The recent admission was due to loss of consciousness after intravenous injection of diluted heroin with unknown filler.