Smoothed particle hydrodynamics based FSI simulation of the native and mechanical heart valves in a patient-specific aortic model.

The failure of the aortic heart valve is common, resulting in deterioration of the pumping function of the heart. For the end stage valve failure, bi-leaflet mechanical valve (most popular artificial valve) is implanted. However, due to its non-physiological behaviour, a significant alteration is observed in the normal haemodynamics of the aorta.

Clinical profile, prognostic indicators and outcome of Wilson's disease in children: a hospital based study.

Background: Wilson's disease is a common metabolic disease of the tropics, which is treatable, if diagnosed early. In the paediatric group, the manifestations are mainly hepatic.

Aims: The objective was to study the varied presentations of the disease and to evaluate the diagnostic values of conventional tests in children.