Cu-/Lu-Cetuximab Theranostic Pair: May the Single Cu-Cetuximab Diagnostic Scan Be Acquired at Any Time After Injection?

Two independent equations were recently proposed for estimating Lu-cetuximab cumulative activity, in a preclinical situation, from an initial Cu-cetuximab diagnostic scan acquired at peak time of decay-uncorrected () or decay-corrected () time-activity curve of trapped Cu-cetuximab, respectively. The standard uptake ratio (SUR) measured at or turned out to be a key metric in each equation, respectively. However, acquiring the diagnostic scan at or might be a limitation of the proposed method.

Estimation of Cumulative Activity of Lu-Cetuximab from a Single Diagnostic Cu-Cetuximab Scan.

This study aimed at investigating whether a single diagnostic Cu-cetuximab scan might predict therapeutic Lu-cetuximab cumulative activity in a preclinical study. The framework of the reversible Patlak-Blasberg analysis was used to derive two independent equations of Lu-cetuximab cumulative activity that involve the tumor-to-blood standard uptake value ratio (i.e.

An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [Cu]Cu-SARTATE.

In a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [/Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblastoma lesions in pediatric patients whose widespread metastases survive initial therapy as minimal residual disease (MRD). MRD may be detected by [Cu]Cu-SARTATE and subsequently treated by [Cu]Cu-SARTATE.

Modelling analysis of centroid curves of olfactory habituation in humans.

Previously published experiments established the time-course of olfactory habituation in humans, and extracted 3 centroid curves from clustering analysis that reflected high, middle and low habituation. The aim of the current theoretical study was to further analyse these previous experimental data by developing a mathematical modelling analysis designed for fitting the 3 curves from a general equation. After adjusting equation parameters for each curve, fitting equation outcomes on experimental data yielded high correlation coefficients of 0.

Correction to: Comparison of three-parameter kinetic model analysis to standard Patlak's analysis in F-FDG PET imaging of lung cancer patients.

Following publication of the original article [1], the authors flagged that the author affiliations detailed in the article are incorrect for the authors M. L. Calcagni and A.