Publications by authors named "Laetitia LeGoff"
Giardia duodenalis induces paracellular bacterial translocation and causes postinfectious visceral hypersensitivity.
Am J Physiol Gastrointest Liver Physiol
April 2016
Article Synopsis
- IBS (Irritable Bowel Syndrome) is a common digestive disorder marked by abdominal pain and changes in bowel habits, often following infections like gastroenteritis.
- Giardia duodenalis, a water-borne pathogen, can lead to complications such as GI malabsorption and may be linked to postinfectious IBS (PI-IBS).
- A new study using neonatal rats infected with Giardia shows that even after clearing the infection, rats developed hypersensitivity and gut changes, suggesting a model for understanding the mechanisms behind PI-IBS.
Human filarial parasites cause chronic infection associated with long-term down-regulation of the host's immune response. We show here that CD4+ T cell regulation is the main determinant of parasite survival. In a laboratory model of infection, using Litomosoides sigmodontis in BALB/c mice, parasites establish for >60 days in the thoracic cavity.
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