Publications by authors named "Laetitia Gosselin"
Article Synopsis
- The study investigated the prevalence and bleeding risk associated with drug interactions between apixaban or rivaroxaban and certain CYP3A4 and P-glycoprotein inhibitors in patients with atrial fibrillation (AF).
- Using a cohort from the French healthcare database (2014-2019), 10,392 AF patients on these medications were analyzed, with a focus on hospitalization due to bleeding as the primary outcome.
- The findings revealed a 38.9% prevalence of drug-drug interactions, but no significant association with increased hospitalization for bleeding; factors like age and male gender were related to higher bleeding risk instead.
Purpose: This systematic review and meta-analysis aimed to determine whether tramadol intake increases the risk of bleeding in patients receiving oral anticoagulants.
Methods: This systematic review was registered on PROSPERO, CRD42022327230. We searched PubMed and Embase up to 14 April 2022, and references and citations of included studies were screened.