Publications by authors named "Laetitia Begue"
Which risk score best predicts cardiovascular outcome in pregnant women with congenital heart disease?
Eur Heart J Qual Care Clin Outcomes
February 2023
Article Synopsis
- Managing pregnancy in women with congenital heart disease (CHD) is complex due to changes in cardiovascular conditions during pregnancy.
- A study evaluated the effectiveness of five existing risk assessment scores in predicting maternal complications for 104 pregnancies involving 65 women with CHD.
- The findings showed that the modified WHO score was more accurate in predicting cardiovascular outcomes compared to the other four scores, indicating a need for improved risk assessment tools for this population.
Pregnancy in MNGIE: a clinical and metabolic honeymoon.
Ann Clin Transl Neurol
December 2020
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an inherited disease caused by a deficiency in thymidine phosphorylase and characterized by elevated systemic deoxyribonucleotides and gastrointestinal (GI) and neurological manifestations. We report the clinical and biochemical manifestations that were evaluated in a single patient before, during, and after pregnancy, over a period of 7 years. GI symptoms significantly improved, and plasma deoxyribonucleotide concentrations decreased during pregnancy.
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- This study aimed to evaluate if the side (right or left) of congenital diaphragmatic hernia (CDH) influences the survival chances of newborns in intensive care.
- Analyzed data from 506 cases showed a higher survival rate for left CDH (74%) compared to right CDH (49%), but the side alone wasn’t directly linked to increased mortality after accounting for other factors.
- Key findings indicated that liver herniation and lung-to-head ratio are significant predictors of mortality, while the laterality of CDH did not significantly affect survival rates after adjustments.
Objective: The objective of the investigation was to study the relationship between gestational age at diagnosis and mortality and morbidity in fetuses with an isolated congenital diaphragmatic hernia.
Study Design: Between January 2008 and November 2013, 377 live births with isolated congenital diaphragmatic hernia diagnosed antenatally at a known gestational age were recorded in the database of the French National Center for Rare Diseases. The primary outcome studied was mortality estimated at 28 days and at 6 months.