High fat in blood and body and increased risk of clinically diagnosed non-alcoholic fatty liver disease in 105,981 individuals.

Background And Aims: High caloric diets rich in fat and carbohydrates lead to increased fat accumulation in adipose tissue and blood. This may lead to increased risk of non-alcoholic fatty liver disease. We hypothesized that baseline high nonfasting plasma triglycerides, body mass index (BMI), and waist circumference, individually and combined, associate with increased risk of clinically diagnosed non-alcoholic fatty liver disease during follow-up.

[Appendicitis in late pregnancy].

Appendicitis in pregnancy is correlated with high morbidity especially for the child. However, the diagnosis is difficult to determine due to subtle signs. This is a case report of a pregnant woman who despite being past due date and having progressive abdominal pain was sent home twice before arriving by ambulance severely affected by a perforated appendix.

Pharmacokinetics of ingenol mebutate gel under maximum use conditions in large treatment areas.

Purpose: Actinic keratoses (AKs) exist on a continuum with squamous cell carcinoma and can occur as sub-clinical and clinically visible lesions in cancerized fields on sun-damaged skin. Ingenol mebutate effectively treats AKs on areas up to 25 cm, but actinic keratosis can affect larger areas of skin. This trial evaluated systemic exposure and safety of ingenol mebutate gel on larger areas of skin under maximum use conditions.