The prognostic and predictive impact of mutations in deficient mismatch repair/microsatellite instability-high colorectal cancer: systematic review/meta-analysis.

The authors present a systematic review/meta-analysis of the impact of mutations on prognosis and immune checkpoint inhibitor (ICI) response in deficient mismatch repair/microsatellite instability-high colorectal cancer. Hazard ratios for overall survival and odds ratios for objective response rate to ICIs were calculated in -mutated versus wild-type patients. After screening, nine and three studies, respectively, were included for analysis of prognosis (analysis A) and ICI response (analysis B).

Outcomes following immunotherapy re-challenge after immune-related adverse event: systematic review and meta-analysis.

Given the inconclusive evidence behind the safety and efficacy of immune checkpoint inhibitors re-challenge, herein, we have conducted a systematic review and meta-analysis to synthesize available data. PubMed, Embase, Cochrane Database, and ASCO and ESMO were searched for studies published from conception to March 2020. Pooled incidence of recurrent immune-related adverse events (irAEs), objective response rates, and odds ratios for irAEs at initial versus re-treatment were calculated.

Treatment-Related Adverse Events of Combination Immune Checkpoint Inhibitors: Systematic Review and Meta-Analysis.

Although clinical practice guidelines for the management of Immune Checkpoint Inhibitor (ICI)-related adverse events have recently been published, precise and nuanced toxicity data for combination ICI therapy are lacking. Therefore, herein we have conducted a systematic review and meta-analysis of published clinical trials on combination ICI to synthesize the treatment-related adverse event (TRAE) profile of combination ICI therapy. PUBMED, EMBASE, and the Cochrane Database/EBM were searched for eligible studies.

Association Between the Functional SNP and Risk of Digestive System Cancer: Updated Meta-analysis.

Background/aim: Previous association studies have linked the functional miR-146a SNP rs2910164 with risk of digestive system cancer; however, the results of these studies are inconclusive and inconsistent. The objective of the following study is to provide an up-to-date and comprehensive meta-analysis of the association of miR-146a rs2910164 and digestive system cancer risk.

Patients And Methods: We searched the PUBMED/MEDLINE and Cochrane/EBM databases.