Publications by authors named "Ladnyĭ A"

With a purpose to study the state of platelet haemostasis and vasoactive prostanoids system 78 patients with ischemic heart disease aged 28 to 59 years were examined. Among them there were 22 patients with "isolated" hypo-alpha-cholesterolemia and 14 patients who had hypo-alpha-cholesterolemia combined with hypertriglyceridemia (HTG). The data obtained show that hypo-alpha-cholesterolemia is accompanied by platelet disorders aggravation and characterized by activated platelet percentage growth.

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The examination of 194 patients with coronary heart disease concurrent with clinical manifestations of angina pectoris established that the development of coronary atherosclerosis was accompanied by suppressed prostacyclin (PGI2) synthesis and increased thromboxane A2 (TxA2) leukotriene (LT) synthesis. The activation of synthesis of the vasoconstrictor and proaggregate TxA2 depended on the severity of clinical signs of angina pectoris. The imbalance of PGI2 to- TxA2 metabolite ratios was associated with dyslipidemias and the extent of coronary atherosclerosis.

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A study is presented of the reactions of prostacyclin-thromboxane system and functions of thrombocytes to physical loads inducing myocardial ischemia in patients with ischemic heart disease of different age groups. Examined were 62 patients with stable stenocardia of the II and III functional classes. Age of the patients: from 44 to 60 years.

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Computerized devices were used for evaluation of the state of pulmonary ventilation and central hemodynamics in 32 patients with pulmonary tuberculosis depending on the spread of the specific process. Patients with limited changes in the lungs, showed disorders of bronchial patency and compensatory increase of organic ejection of the right ventricle. In the presence of spread changes in the lungs the above mentioned changes were supplemented by restrictive ventilation disorders with a reduction of the contractile myocardial capacity.

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As a result of a study of 262 patients with chronic destructive tuberculosis of the lungs the authors revealed that these patients showed personality disorders that impede adequate treatment. Psychotherapy carried out in 5.2% of patients aimed at correction of personality disorders enabled to increase treatment efficacy of chronic destructive pulmonary tuberculosis.

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The experience gained in the complex approach to the organization of day hospitals at curative and preventive facilities in Lvov and Lvov region is described. The problems in the delivery of in-patient care for the population formed the basis for the drafting of programme aimed at developing the network of out-patient departments of active treatment of patients. The description is given of the main components of day hospitals activities, schedule of work, indications and contra-indications for the treatment of patients.

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The basic general methodological assessments of public health quality are considered. An analogy is drawn with quality assessment in industry, approaches to the development of multi-aspect and multi-parameter assessment of public health quality are substantiated. A term of "qualimetry " of public health is suggested.

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Lung ventilation and central hemodynamics in the course of treatment of 43 patients with pulmonary tuberculosis were studied. Registered ventilation and hemodynamic disturbances disappeared with an effectively conducted chemotherapy.

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Results of treatment of patients with stable stenocardia by means of nitrates indicate that the antianginal effect was parallelled by an increase of the sensitivity of thrombocytes to prostacyclin and level of the plasma metabolite prostacyclin. The hypolipidemic effect of miscleron therapy is accompanied in patients with ischemic heart disease by reduction of the aggregation properties of thrombocytes and level of the metabolite thromboxane A2 in the plasma. The rationality of combined treatment with miscleron and nitrates is substantiated from the position of aimed effect on important links of atherogenesis and ischemic heart disease, namely functional properties of thrombocytes, prostacyclin-thromboxane ratio and level of blood lipids.

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The authors studied the functional activity of thrombocytes, levels of plasma and thrombocytic cyclic AMP (cAMP) in the dynamics of a veloergometric test in patients with IHD and neurocirculatory dystonia. The revealed signs of hyperactivation of thrombocytes and absence of compensatory response of cAMP in IHD patients against the background of thresholds loads allows to improve the quality of prediction of thrombotic complications and control of treatment efficacy with agents possessing antithrombocytic activity.

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On-stage development of subsystems, automating the work of a polyclinic, previously was oriented to the departments of Automated Systems of Management at industrial enterprises and computers of ES type, at present a number of subsystems has been developed and are being developed which are oriented to personal computers and mini-computers of SM type which are being installed directly at the polyclinics. All subsystems are consolidated on the basis of systems approach.

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Day hospitals are successfully functioning at some polyclinics. The treatment in a day hospital shortens the period of temporary disability, enhances the effect of treatment while cutting down its cost. Indications for ambulatory surgical intervention are expanding which sharply decreases the number of purulent complications.

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