Publications by authors named "Ladan Pourabdi"
Article Synopsis
- A new series of coumarin derivatives linked to benzyl triazole was synthesized and tested for their effectiveness against enzymes related to Alzheimer's disease, specifically 15-lipoxygenase and cholinesterases.
- While most of these compounds showed only weak to moderate effects, some standouts exhibited strong neuroprotective properties, outperforming the standard drug quercetin in cell models.
- Further studies, including docking and kinetic analysis, indicated that the top-performing compounds could be promising candidates for future development in treating Alzheimer's disease, due to their solid inhibition of targeted enzymes and prevention of amyloid aggregation.
A series of tacrine-based pyrazolo[4',3':5,6]pyrano[2,3-b]quinolines and related compounds were designed and synthesized for targeting AChE, BuChE and 15-LOX enzymes in the field of Alzheimer's disease therapy. Most of compounds showed potent activity against cholinesterases and mild potency toward 15-LOX enzyme. In particular, compounds 29, 32 and 40 displayed inhibition at nano-molar level against AChE and BuChE (IC50s = 0.
View Article and Find Full Text PDFA crude phenolic glycolipid extract from Mycobacterium bovis BCG was fractionated by column chromatography. A reversed-phase high performance liquid chromatography (HPLC) method with UV detection at 275 nm was developed for simultaneous detection and separation of phenolic glycolipids (PGLs) in Mycobacterium bovis BCG. This analysis provides a good resolution.
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