Publications by authors named "Lada Skvorova"
Article Synopsis
- Maternal diabetes is linked to common congenital cardiovascular defects, prompting a study on gene expression in hearts exposed to diabetes during embryonic development.
- Increased levels of hypoxia and the protein HIF-1α were observed in diabetes-exposed hearts at a critical developmental stage (E10.5), along with elevated cardiac Vegfa levels, suggesting potential causes for heart defects.
- Findings indicate that maternal diabetes disrupts the expression of key genes related to heart development and tissue remodeling, potentially affecting heart maturation and outcomes in pregnancies affected by diabetes.
Background: Diabetic cardiomyopathy is associated with a number of functional and structural pathological changes such as left ventricular dysfunction, cardiac remodeling, and apoptosis. The primary cause of diabetic cardiomyopathy is hyperglycemia, the metabolic hallmark of diabetes. Recent studies have shown that a diabetic environment suppresses hypoxia-inducible factor (HIF)-1α protein stability and function.
View Article and Find Full Text PDFCardiovascular malformations are the most common manifestation of diabetic embryopathy. The molecular mechanisms underlying the teratogenic effect of maternal diabetes have not been fully elucidated. Using genome-wide expression profiling, we previously demonstrated that exposure to maternal diabetes resulted in dysregulation of the hypoxia-inducible factor 1 (HIF-1) pathway in the developing embryo.
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