Publications by authors named "Lacy Reynolds"
Article Synopsis
- - Mitochondria play a vital role in respiration and are particularly important in the liver for processes like gluconeogenesis, but during nonalcoholic fatty liver disease (NAFLD), they can produce reactive oxygen species (ROS) that harm liver cells and contribute to inflammation and insulin resistance.
- - Studies in mice showed that increased fatty acid delivery led to greater oxidative metabolism, which in turn elevated stress and inflammation, while knockout of a specific enzyme (Pck1) reduced these negative effects, indicating a strong link between metabolic processes and oxidative damage.
- - Using metformin to lower oxidative metabolism in the liver normalized the associated anabolic pathways and reduced inflammation, linking oxidative stress in human NAFLD cases to metabolic changes from high
Background & Aims: Dietary intake of the natural omega-3 fatty acid docosahexaenoic acid (DHA) has been implicated in protecting patients with viral hepatitis B or C from developing hepatocellular carcinoma (HCC). Little is known about the effects of DHA on established solid tumors. Here we describe a low-density lipoprotein-based nanoparticle that acts as a transporter for unesterified DHA (LDL-DHA) and demonstrates selective cytotoxicity toward HCC cells.
View Article and Find Full Text PDFAim: The natural omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has recently been credited for possessing anticancer properties. Herein, we investigate the cytotoxic actions of DHA-loaded low-density lipoprotein (LDL) nanoparticles in normal and liver cancer cells.
Materials & Methods: LDL-DHA nanoparticles were prepared and subjected to extensive biophysical characterization.