Publications by authors named "Lacna A"
Article Synopsis
- * This study evaluated the safety and efficacy of individualized high-dose ATG with therapeutic drug monitoring in pediatric patients at high risk for GvHD and rejection, aiming for specific drug exposure levels before and after CBT.
- * Results showed that 86% and 91% of patients achieved the target ATG exposure levels, with a low incidence of acute GvHD (34%) and rejection (9%), while the overall survival rate was 75
Anti-thymocyte globulin (ATG), a polyclonal antibody, is used in allogeneic hematopoietic cell transplantation (HCT) to prevent graft-vs.-host-disease (GvHD) and graft failure (GF). Overexposure to ATG leads to poor early T-cell recovery, which is associated with viral infections and poor survival.
View Article and Find Full Text PDFOmidubicel (nicotinamide-expanded cord blood) is a potential alternative source for allogeneic hematopoietic cell transplantation (HCT) when an HLA-identical donor is lacking. A phase I/II trial with standalone omidubicel HCT showed rapid and robust neutrophil and platelet engraftment. In this study, we evaluated the immune reconstitution (IR) of patients receiving omidubicel grafts during the first 6 months post-transplant, as IR is critical for favorable outcomes of the procedure.
View Article and Find Full Text PDFArticle Synopsis
- * Overdosing can lead to poor T cell immune recovery and increase relapse and viral reactivation rates, while underdosing raises GvHD risks, both heightening mortality rates.
- * The manuscript introduces a new liquid chromatography tandem-mass spectrometry (LC-MS/MS) method for accurately measuring active ATG levels in plasma, aiming to improve patient dosing and survival outcomes in clinical settings.