Publications by authors named "Lachoff H"
Article Synopsis
- - The study investigated the role of mGlu5 receptors in individuals with methamphetamine use disorder (MUD) compared to a control group, focusing on cognitive performance and brain activity measured by PET scans.
- - Results showed no significant differences in mGlu5 levels between MUD participants and controls, but MUD individuals performed worse on certain cognitive tests, particularly in spatial working memory.
- - Findings suggest that while mGlu5 receptors are not downregulated in abstinent MUD patients, targeting these receptors could potentially enhance cognitive functioning, especially in verbal learning tasks.
Sensory perception can be severely degraded after peripheral injuries that disrupt the functional organization of the sensory maps in somatosensory cortex, even after nerve regeneration has occurred. Rehabilitation involving sensory retraining can improve perceptual function, presumably through plasticity mechanisms in the somatosensory processing network. However, virtually nothing is known about the effects of rehabilitation strategies on brain organization, or where the effects are mediated.
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