Super-resolution ultrasound imaging of ischaemia flow: An in silico study.

Super-resolution ultrasound (SRU) is a new ultrasound imaging mode that promises to facilitate the detection of microvascular disease by providing new vascular bio-markers that are directly linked to microvascular pathophysiology, thereby augmenting current knowledge and potentially enabling new treatment. Such a capability can be developed through thorough understanding as articulated by means of mathematical models. In this study, a 2D numerical flow model is adopted for generating flow adaptation in response to ischaemia, in order to determine the ability of SRU to register the resulting flow perturbations.