Publications by authors named "Labenz J"

In Germany, there are no uniform hospital standards for the transparent calculation of medical staffing requirements in hospitals. This is particularly true for outpatient services.The ALGK conducted a member survey via the link https://de.

View Article and Find Full Text PDF
Article Synopsis
  • Proton pump inhibitors (PPIs) are the primary treatment for gastro-esophageal reflux disease (GERD), but many patients experience persistent symptoms despite using them, termed PPI-refractory GERD.
  • There is a lack of specific guidelines for managing these patients, leading to prolonged ineffective treatment or premature discontinuation, often without proper assessment of their dissatisfaction.
  • The article suggests that rather than relying solely on PPI response, the focus should be on determining if the symptoms are indeed caused by GERD, and it reviews both traditional and new surgical options for treating those with PPI-refractory GERD.
View Article and Find Full Text PDF

Background & Aims: Data on the association between proton pump inhibitor (PPI) use and hepatic encephalopathy (HE) are conflicting, and data from multicentre studies are scarce. The aim of this study was to dissect the potential association between PPI use and minimal (MHE) and overt HE (OHE).

Methods: Data from patients with cirrhosis recruited at seven centres across Europe and the US were analysed.

View Article and Find Full Text PDF

Background: Atrial fibrillation (AF) ablation is increasingly effective for managing heart rhythm but poses risks like esophageal fistulas. Minimizing esophageal thermal lesions while simplifying procedures is crucial.

Methods: This prospective study involved 100 consecutive AF patients undergoing cryoballoon ablation with simplified sedation, without esophageal temperature monitoring.

View Article and Find Full Text PDF
Article Synopsis
  • Minimal hepatic encephalopathy (MHE) is linked to a greater risk of overt hepatic encephalopathy (OHE) as measured by the portosystemic hepatic encephalopathy score (PHES).
  • A multicenter study followed patients with MHE to see if worse PHES results led to a progressively higher risk of developing OHE.
  • Findings showed that while abnormal PHES indicates a higher chance of OHE, there isn't a stepwise increase in risk as PHES scores worsen beyond a certain threshold.
View Article and Find Full Text PDF

Background: Despite deprescribing initiatives to curb overutilization of proton pump inhibitors (PPIs), achieving meaningful reductions in PPI use is proving a challenge.

Summary: An international group of primary care doctors and gastroenterologists examined the literature surrounding PPI use and use-reduction to clarify: (i) what constitutes rational PPI prescribing; (ii) when and in whom PPI use-reduction should be attempted; and (iii) what strategies to use when attempting PPI use-reduction.

Key Messages: Before starting a PPI for reflux-like symptoms, patients should be educated on potential causes and alternative approaches including dietary and lifestyle modification, weight loss, and relaxation strategies.

View Article and Find Full Text PDF

Background And Aims: Minimal hepatic encephalopathy (MHE) is a frequent complication in patients with liver cirrhosis. Its impact on predicting the development of overt hepatic encephalopathy (OHE) and survival has not been studied in large multicenter studies.

Methods: Data from patients recruited at eight centers across Europe and the United States were analyzed.

View Article and Find Full Text PDF

Background: Patients with cirrhosis and especially those with HE may have impaired driving skills and may be prone to car accidents. This proof-of-concept study aimed to develop and evaluate the applicability of a virtual reality (VR)-based driving test in patients with cirrhosis. Additionally, the association between the results in the VR test and car accidents was investigated.

View Article and Find Full Text PDF

Objectives: The aim of our study was to compare the results of endoscopy and manometry with regard to the presence and longitudinal size of hiatal hernias using a cohort of patients with PPI-refractory reflux symptoms. In addition, we aimed to investigate the clinical relevance of hiatal hernias and their size in relation to the occurrence of GERD.

Methods: Five hundred patients with suspected GERD due to typical reflux symptoms (heartburn and regurgitation) and inadequate response to PPI therapy underwent standardized screening at a reflux center.

View Article and Find Full Text PDF

In recent years significant progress has been made in the treatment of eosinophilic esophagitis (EoE), especially in the area of topical corticosteroids. Novel EoE-specific formulations have been developed and first approvals have been obtained for induction and maintenance of remission in adult EoE patients with the orodispersible budesonide tablet in Germany and other European and non-EU countries. A novel budesonide oral suspension is currently under priority review by the FDA for first approval in the U.

View Article and Find Full Text PDF
Article Synopsis
  • A study aimed to determine the prevalence of minimal hepatic encephalopathy (MHE) in different patient subgroups suffering from cirrhosis, to better identify those at higher risk.
  • The research involved 1,868 patients from 10 centers in Europe and the U.S. and found that 35% had MHE, with notable variations based on liver disease severity.
  • Results showed lower prevalence in early-stage cirrhosis (CP A at 25%) compared to advanced stages (CP B at 42% and CP C at 52%), suggesting the need for personalized screening strategies based on disease stage and MELD scores.
View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to determine if bicarbonate-rich mineral water, Staatl. Fachingen STILL, is more effective than regular mineral water in relieving heartburn in adults who experience frequent episodes.
  • - In a randomized, double-blind trial with 148 participants, those drinking the bicarbonate-rich water showed a significantly higher improvement in heartburn symptoms and overall quality of life compared to the placebo group.
  • - The findings suggest that Staatl. Fachingen STILL not only reduces heartburn symptoms but also enhances health-related quality of life, with minimal side effects reported.
View Article and Find Full Text PDF

Background: The number of patients with proton pump inhibitor (PPI)-refractory reflux symptoms is underestimated since many patients resign after an unsuccessful therapy attempt. Thus, it would be useful having a non-invasive tool that can help identify true gastroesophageal reflux disease (GERD) patients in order to manage them early and properly. The GerdQ is a validated tool developed for this purpose but its applicability in PPI-refractory patients has not yet been investigated.

View Article and Find Full Text PDF

Even after decades of research and pharmaceutical development, cancer is still one of the most common causes of death in the western population and the management of cancer will remain a major challenge of medical research. One of the most common types of cancer is colorectal cancer (CRC). Prevention by detection of early-stage precursors is the most reliable method to prevent CRC development.

View Article and Find Full Text PDF

Introduction: This systematic review summarizes published data on Menthacarin, the proprietary combination of peppermint oil and caraway oil, in the treatment of functional gastrointestinal disorders. Efficacy was assessed by meta-analysis of placebo-controlled trials.

Methods: We searched PubMed, the Cochrane Library, and the manufacturer's information system for clinical studies investigating the safety and efficacy of Menthacarin.

View Article and Find Full Text PDF

Diverticulosis and diverticular disease are ranked among the most common gastroenterological diseases and conditions. While for many years diverticulitis was found to be mainly an event occurring in the elder population, more recent work in epidemiology demonstrates increasing frequency in younger subjects. In addition, there is a noticeable trend towards more complicated disease.

View Article and Find Full Text PDF

Diverticulosis and diverticular disease are ranked among the most common gastroenterological diseases and conditions. While for many years diverticulitis was found to be mainly an event occurring in the elder population, more recent work in epidemiology demonstrates increasing frequency in younger subjects. In addition, there is a noticeable trend towards more complicated disease.

View Article and Find Full Text PDF

Background: Burnout in the field of gastroenterology is an under-researched phenomenon. So far, only a few studies have dealt with this topic. There are large geographical variations in burnout rates with 16-20% of gastroenterologists in Mexico and Germany being at risk or having burnout, 30-40% in the United Kingdom, and 50-55% in South Korea, Canada, and the USA.

View Article and Find Full Text PDF

Eosinophilic esophagitis (EoE) is the most common cause of esophageal food impaction (EFI). Approaches to management of EFI due to EoE have not been well characterized. We conducted a web-based survey to understand approaches to management of EFI due to EoE among endoscopists.

View Article and Find Full Text PDF