A Comparative Efficacy Evaluation of Recombinant Topical Thrombin (RECOTHROM) With A Gelatin Sponge Carrier Versus Topical Oxidized Regenerated Cellulose (TABOTAMP/SURGICEL) In A Porcine Liver Bleeding Model.

Purpose: Topical hemostatic agents can be classified as active or passive. This study compared the hemostatic efficacy of an active agent, recombinant thrombin (RECOTHROM [rT]) plus gelatin sponge carrier versus a passive agent, oxidized regenerated cellulose (TABOTAMP/SURGICEL [ORC]), in a porcine liver abrasion model.

Materials And Methods: Eight pigs were used, four of them were heparinized.

An Efficacy Comparison of Two Hemostatic Agents in a Porcine Liver Bleeding Model: Gelatin/Thrombin Flowable Matrix versus Collagen/Thrombin Powder.

Management of bleeding during surgery can be aided by the application of topical hemostatic agents. This study compared the hemostatic efficacy of a new powder agent containing collagen, chondroitin sulfate, and thrombin (PCCT) with a flowable gelatin-thrombin matrix with smooth particles (SmGM) in a porcine liver bleeding model. Lesions 4-6 mm deep and ∼10 mm in diameter were created in porcine livers and treated with either SmGM or PCCT.

Refinement of pig retroperfusion technique: Global retroperfusion with ligation of the azygos connection preserves hemodynamic function in an acute infarction model in pigs (Sus scrofa domestica).

In ischemic hearts, venous retroperfusion is a potential myocardial revascularization strategy. This study aimed to refine the technical and functional aspects of a pig model of acute myocardial infarction and retroperfusion with respect to the azygos connection. Global retroperfusion after ligation of the ramus interventricularis paraconalis (equivalent to the left anterior descending artery in humans) was performed in 16 Landrace pigs (Sus scrofa domestica).

Electromyographic response persists after peripheral transection: endorsement of current concepts in recurrent laryngeal nerve monitoring in a porcine model.

Background: Recurrent laryngeal nerve palsy is a serious complication of endocrine surgery to the neck. Permanent lesions are still occurring in about one in a hundred, despite standardized surgical approach to the nerve and the availability of recurrent laryngeal nerve monitoring. Intraoperative recurrent laryngeal nerve monitoring is based on the visual or acoustic registration of evoked electromyography of the laryngeal muscles.

Dielectric relaxation of ultrathin films of supported polysulfone.

The dynamic glass transition (alpha relaxation, structural relaxation) of ultrathin polysulfone films prepared between aluminum electrodes is investigated by dielectric relaxation spectroscopy. As a main result, it is found that the glass transition temperature Tg does not depend on the thickness of the polymeric layer down to a thickness of 10 nm. For thicknesses lower than 10 nm, an increase of Tg is observed.

Feasibility of the laryngeal tube airway for artificial ventilation in pigs and comparison with the laryngeal mask airway.

Airway management in anesthetized pigs is known to be technically demanding, and the 'gold standard' technique of endotracheal intubation is particularly difficult to master. The authors investigated the feasibility of the laryngeal tube as an alternative technique for airway management in German Landrace pigs (n = 5). They compared this method with the laryngeal mask, which is considered to be an effective yet relatively straightforward tool for porcine airway management.

A polyhydroxybutyrate biodegradable stent: preliminary experience in the rabbit.

Purpose: The lifelong persistence of foreign bodies within the arteries may contribute to restenosis. Thus, biodegradable devices might decrease recurrence rates.

Methods: Eleven polyhydroxybutyrate biodegradable stents and 13 tantalum stents were implanted into the iliac arteries of New Zealand white rabbits for up to 30 weeks.

[First results in an animal model on stents sheathed with a polytetrafluoroethylene membrane].

Objectives: Mechanisms of restenosis after coronary stent implantation include marked intimal proliferation as well as vascular tissue protrusion through the meshes. Thus, stent sheathed with membranes may be an alternative to improve the long-term outcome.

Methods: Seventeen cylindric serpentine shaped 316L stainless steel stents (nominal diameter 3.

[Evaluation of authorised experiments on laboratory animals with regard to the aim of the research to be carried out, its scientific usefulness and its medical relevance].

As a follow-up to our recent study about the suffering of laboratory animals in experiments, we investigated if results obtained from animal experiments performed in accordance with the German animal welfare act were published, and if these led to consequences in the medical field, especially in published medical literature. According to the German animal welfare act animal experiments must be applied for at a local ethics committee which approves these experiments. All applications (51) made between 1991 and 1993 were examined in co-operation with some of the authors and the authorities.

Experimental model for transplantation of a modified free myocutaneous gracilis flap to an irradiated neck region in rats.

In 102 Wistar rats (male, weight 300-500 g), a modified free myocutaneous gracilis flap was obtained from the groin and transplanted to the neck. To create a pre-irradiated transplant bed, a local area of the neck was irradiated preoperatively with 30 Gy (fractionation: 3 x 10 Gy) in 30 animals, and with 50 Gy (fractionation: 5 x 10 Gy) in a further 30 animals. The interval between preoperative irradiation and transplantation was 4 weeks.

Improved technique for cannulation of the murine thoracic duct: a valuable tool for the dissection of immune responses.

Several experimental approaches have been used in the past for the cannulation of the thoracic duct in mice. Most, however, are characterized by a modest reproducibility and a low lymph yield. Here, we describe a cannulation technique modified with respect to the anesthesia, the use of a silicone cannula and a simple and efficient intraabdominal fixation of the drain.