Publications by authors named "LaBianca S"
Article Synopsis
- Large biobank samples allow researchers to combine detailed family histories and genetic data to investigate complex diseases.
- The study introduces a new method called Pearson-Aitken Family Genetic Risk Scores (PA-FGRS) to estimate disease risk based on family medical histories.
- Applying PA-FGRS to major depressive disorder (MDD) shows improved understanding of genetic factors and clinical variability, and enhances the effectiveness of genetic studies across different complex conditions.
Attention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations. The genetic contributions to such heterogeneity are not well understood. Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 14,084 diagnosed individuals.
View Article and Find Full Text PDFObjective: Attention deficit hyperactivity disorder (ADHD) is a multifactorial neurodevelopmental disorder, yet the interplay between ADHD polygenic risk scores (PRSs) and other risk factors remains relatively unexplored. The authors investigated associations, confounding, and interactions of ADHD PRS with birth-related, somatic, and psychosocial factors previously associated with ADHD.
Methods: Participants included a random general population sample (N=21,578) and individuals diagnosed with ADHD (N=13,697) from the genotyped Danish iPSYCH2012 case cohort, born between 1981 and 2005.
Objective: Stimulant medications are effective for treating attention deficit hyperactivity disorder (ADHD), yet discontinuation and switch to nonstimulant ADHD medications are common. This study aimed to identify genetic, clinical, and sociodemographic factors influencing stimulant treatment initiation, discontinuation, and switch to nonstimulants in individuals with ADHD.
Methods: The authors obtained genetic and national register data for 9,133 individuals with ADHD from the Danish iPSYCH2012 sample and defined stimulant treatment initiation, discontinuation, and switch from prescriptions.
Article Synopsis
- Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often occur together and have genetic components influencing their risk.
- In a study of 39 families, researchers found that known genetic variants explained about 10% of the variance in comorbid ASD/ADHD, with lower contributions for ASD (4%) and ADHD (2%) individually.
- The study indicates that individuals with adult ASD/ADHD needing ongoing specialist care carry a higher burden of rare genetic variants compared to unaffected family members, while affected relatives show intermediate levels.
Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum.
J Autism Dev Disord
October 2018
Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occur and show high genetic correlation. With the introduction of DSM-5, there is a new concept of an ASD and/or ADHD spectrum (ASD/ADHD). This study aimed to identify predictors of severity and need of healthcare within this spectrum.
View Article and Find Full Text PDFFamilial hemiplegic migraine (FHM) is a rare autosomal dominant form of migraine with motor aura. We present a case report of a father and son with very similar attacks of hemiplegic migraine and recurrent episodes of accompanying psychoses. Previously, such episodes led to hospitalization and extended clinical examinations, which further worsened the psychoses.
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