Biomimetic Honeycomb-like TiCT MXene/Bacterial Cellulose Aerogel-Based Flexible Pressure Sensor for the Human-Computer Interface.

The pursuit of efficient and accurate human-computer interface design urgently requires high-performance sensors with pressure sensitivity, a wide detection range, and excellent cycling stability. Herein, a biomimetic honeycomb-like TiCT MXene/bacterial cellulose (BC) aerogel with a negative Poisson's ratio (ν = -0.14) synthesized from the bidirectional freeze-drying method is used as the active material for a flexible pressure sensor, which exhibits high sensitivity (20.

Impact of comorbid sleep-disordered breathing on escitalopram treatment in patients newly diagnosed with generalized anxiety disorder: A 12-week prospective observational study.

We aimed to evaluate the presence of sleep-disordered breathing (SDB) in generalized anxiety disorder (GAD) patients and its impacts after 12-week of escitalopram treatment. In this prospective observational study, GAD patients were followed up to determine whether comorbid SDB affects their treatment response. They underwent a home sleep apnea test (HSAT), and oxygen desaturation index ≥5 was considered indicative of SDB.

Neuroprosthetic contact lens enabled sensorimotor system for point-of-care monitoring and feedback of intraocular pressure.

The wearable contact lens that continuously monitors intraocular pressure (IOP) facilitates prompt and early-state medical treatments of oculopathies such as glaucoma, postoperative myopia, etc. However, either taking drugs for pre-treatment or delaying the treatment process in the absence of a neural feedback component cannot realize accurate diagnosis or effective treatment. Herein, a neuroprosthetic contact lens enabled sensorimotor system is reported, which consists of a smart contact lens with TiCT Wheatstone bridge structured IOP strain sensor, a TiCT temperature sensor and an IOP point-of-care monitoring/display system.

Downregulation of TGF-β1 in fibro-adipogenic progenitors initiates muscle ectopic mineralization.

In previous studies, we have demonstrated that stress response-induced high glucocorticoid levels could be the underlying cause of traumatic heterotopic ossification (HO), and we have developed a glucocorticoid-induced ectopic mineralization (EM) mouse model by systemic administration of a high dose of dexamethasone (DEX) to animals with muscle injury induced by cardiotoxin injection. In this model, dystrophic calcification (DC) developed into HO in a cell autonomous manner. However, it is not clear how DC is formed after DEX treatment.

Iliopsoas fibrosis after revision of total hip arthroplasty revealed by Ga-FAPI PET/CT: a case report.

Background: Total hip arthroplasty (THA) is a well-established surgical procedure that has been extensively validated to alleviate pain, enhance joint function, improve the ability to perform daily activities, and enhance overall quality of life. However, this procedure is associated with certain complications, among which skeletal muscle fibrosis is a frequently overlooked but significant complication that can lead to persistent pain. Currently, there is no effective method for diagnosing skeletal muscle fibrosis following total hip arthroplasty.

An Ultrasensitive TiCT MXene-based Soft Contact Lens for Continuous and Nondestructive Intraocular Pressure Monitoring.

Wearable soft contact lens sensors for continuous and nondestructive intraocular pressure (IOP) monitoring are highly desired as glaucoma and postoperative myopia patients grow, especially as the eyestrain crowd increases. Herein, a smart closed-loop system is presented that combines a TiCT MXene-based soft contact lens (MX-CLS) sensor, wireless data transmission units, display, and warning components to realize continuous and nondestructive IOP monitoring/real-time display. The fabricated MX-CLS device exhibits an extremely high sensitivity of 7.

MXene based flexible photodetectors: progress, challenges, and opportunities.

The growing interest in applying 2D transition-metal carbides and nitrides (MXenes) to diverse application fields such as energy storage and harvesters, catalysts, sensors, optoelectronics, electromagnetic interference shielding and antennas since its first discovery in 2011 is clearly evident. Their intrinsic high conductivity limits the development of MXenes in photodetectors that rely on the semiconducting properties of active materials, while the abundant functional groups on the surface of MXenes provide opportunities for using MXenes as sensing materials in the fabrication of flexible photodetectors. Considerable studies on MXene based photodetectors have been carried out, but the main obstacles include seeking novel semiconducting materials in MXene families, the manufacturing technology, This review highlights the progress, challenges and opportunities in MXene based flexible photodetectors and discusses novel materials, architectures, and approaches that capitalize on our growing understanding of MXenes.

Carbon dot decorated CoO nanozymes responsive to the NIR-II window for mild photothermal-enhanced nanocatalytic therapy.

Although NIR-II laser-mediated photothermal therapy (PTT) is considered as an emerging strategy for tumor therapy, its therapeutic effects are still seriously hampered by low photothermal conversion efficacy, limited tissue penetration depth, and inevitable damage to adjoining healthy tissues. Herein, we report a mild second-near-infrared (NIR-II) photothermal-augmented nanocatalytic therapy (NCT) nanoplatform based on CD@CoO heterojunctions by depositing NIR-II-responsive carbon dots (CDs) onto the surface of CoO nanozymes. The as-prepared CoO nanozymes possess multi-enzyme-mimicking catalytic activity including peroxidase, catalase, and glutathione-peroxidase to realize the cascade amplification of ROS levels owing to the presence of multivalent Co and Co.

Sacubitril/valsartan reduces susceptibility to atrial fibrillation by improving atrial remodeling in spontaneously hypertensive rats.

Aim: Sacubitril/valsartan (Sac/Val, LCZ696), the world's first angiotensin receptor-neprilysin inhibitor (ARNi), has been widely used in the treatment of heart failure. However, the use of Sac/Val in the treatment of atrial fibrillation (AF), especially AF with hypertension, has been less reported. We investigated the effect of Sac/Val on atrial remodeling and hypertension-related AF.

The development of a mouse model to investigate the formation of heterotopic ossification.

Background: Muscle injury and concomitant bone injury are important drivers to induce heterotopic ossification (HO). However, the related roles of muscle and concomitant bone injury in HO formation are still unclear. This study aims to develop a mouse model through the combination of hindlimb amputation (Am) and cardiotoxin (CTX) injection to investigate the mechanism of HO formation.

Diagnostic efficiency of [68 Ga]Ga-DOTA-FAPI-04 in differentiating periprosthetic hip joint infection and aseptic failure.

Purpose: To assess the efficiency of [ Ga]Ga-DOTA-FAPI-04 in diagnosing periprosthetic hip joint infection and establish a diagnostic standard of clinical significance based on uptake pattern.

Methods: [ Ga]Ga-DOTA-FAPI-04 PET/CT was performed in patients with symptomatic hip arthroplasty from December 2019 to July 2022. The reference standard was based on the 2018 Evidence-Based and Validation Criteria.

A TiCT MXene cathode and redox-active electrolyte based flexible Zn-ion microsupercapacitor for integrated pressure sensing application.

Frequently used aqueous electrolytes in MXene-based Zn-ion hybrid microsupercapacitors (MSCs) limit their cycling and rate stability. The use of metal and nonmetal additives in electrolytes for the performance improvement of Zn-ion MSCs is considered a valid method. Herein, we propose an additive assisted Zn(CFSO) electrolyte as a redox-active electrolyte to prepare a flexible MXene-based Zn-ion hybrid MSC by a facile spraying method, and it consists of a conductive TiCT-LiCl current collector and a TiCT-DMSO cathode.

Recombination between NADC34-like and QYYZ-like strain of porcine reproductive and respiratory syndrome virus with high pathogenicity for piglets in China.

Porcine reproductive and respiratory syndrome virus (PRRSV) is an important pathogen that causes huge economic losses to the swine industry worldwide. Here, a novel variant of PRRSV strain named TJnh2021 was isolated from nursery piglets with morbidity rate (75%) and mortality rate (40%) in Tianjin Province of China in 2021. Phylogenetic and molecular evolutionary analyses revealed that TJnh2021 was highly similar to NADC34-like (lineage 1.

Continuous Fabrication of TiCT MXene-Based Braided Coaxial Zinc-Ion Hybrid Supercapacitors with Improved Performance.

TiCT MXene-based coaxial zinc-ion hybrid fiber supercapacitors (FSCs) were fabricated with braided structure, which can be prepared continuously and present excellent flexibility and ultrastability. A sports watch driven by the watch belts which weaved uses the obtained zinc-ion hybrid FSC and LED arrays lighted by the FSCs under embedding into textiles, demonstrating the great potential application in smart wearable textiles. Zinc-ion hybrid fiber supercapacitors (FSCs) are promising energy storages for wearable electronics owing to their high energy density, good flexibility, and weavability.

Ten years of China's new healthcare reform: a longitudinal study on changes in health resources.

Background: China launched a new round of healthcare-system reform in 2009 and proposed the goal of equal and guaranteed essential medical and health services for all by 2020. We aimed to investigate the changes in China's health resources over the past ten years after the healthcare reform.

Methods: Data were collected from the China Statistical Yearbook and China Health Statistics Yearbook from 2009 to 2018.

Progress and Perspectives in Designing Flexible Microsupercapacitors.

Miniaturized flexible microsupercapacitors (MSCs) that can be integrated into self-powered sensing systems, detecting networks, and implantable devices have shown great potential to perfect the stand-alone functional units owing to the robust security, continuously improved energy density, inherence high power density, and long service life. This review summarizes the recent progress made in the development of flexible MSCs and their application in integrated wearable electronics. To meet requirements for the scalable fabrication, minimization design, and easy integration of the flexible MSC, the typical assembled technologies consist of ink printing, photolithography, screen printing, laser etching, etc.

Full-field stress measuring method based on terahertz time-domain spectroscopy.

Terahertz wave has been used to obtain the internal information of materials due to its penetrability to optically opaque materials. In this paper, we propose a full-field stress measuring method using terahertz time-domain spectroscopy. The theoretical model of the method was established based on the stress-optical law, and the method was then validated experimentally.

Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway.

Biomaterials that can harness the intrinsic osteogenic potential of stem cells offer a promising strategy to accelerate bone regeneration and repair. Previously, we had used methacrylated gelatin (GelMA)-based scaffolds to achieve bone formation from human mesenchymal stem cells (hMSCs). In this study, we aimed to further enhance hMSC osteogenesis by incorporating graphene oxide (GO)-based nanosheets into GelMA.

The green-agile supplier selection problem for the medical devices: a hybrid fuzzy decision-making approach.

The supplier selection problem (SSP) is known as one of the major issues in the supply chain management area. In this field, the literature shows that the combination of green and agile indicators has been ignored by researchers. Hence, this research attempts to study the SSP considering green and agile aspects, simultaneously.

Clinical application of PEAK PlasmaBlade to remove distal tracheal granulation in patients after tracheostomy.

Objective: Tracheal granulation is one of the common long term complications in patients after tracheostomy. Hypertrophic tracheal granulation may cause airway obstruction and further operation may be required to recreate an airway. Distal tracheal granulation is clinically challenging because of its position and surgical field limitation.

Knitted TiCT MXene based fiber strain sensor for human-computer interaction.

Fiber-based stretchable electronics with feasibility of weaving into textiles and advantages of light-weight, long-term stability, conformability and easy integration are highly desirable for wearable electronics to realize personalized medicine, artificial intelligence and human health monitoring. Herein, a fiber strain sensor is developed based on the TiCT MXene wrapped by poly(vinylidenefluoride-co-trifluoroethylene) (P(VDF-TrFE)) polymer nanofibers prepared via electrostatic spinning. Owing to the good conductivity of TiCT and unique 3D reticular structure with wave shape, the resistance of TiCT@P(VDF-TrFE) polymer nanofibers changes under external force, thus providing remarkable strain inducted sensing performance.

In-Situ Annealed TiCT MXene Based All-Solid-State Flexible Zn-Ion Hybrid Micro Supercapacitor Array with Enhanced Stability.

Zn-ion hybrid supercapacitors (SCs) are considered as promising energy storage owing to their high energy density compared to traditional SCs. How to realize the miniaturization, patterning, and flexibility of the Zn-ion SCs without affecting the electrochemical performances has special meanings for expanding their applications in wearable integrated electronics. TiCT cathode with outstanding conductivity, unique lamellar structure and good mechanical flexibility has been demonstrated tremendous potential in the design of Zn-ion SCs, but achieving long cycling stability and high rate stability is still big challenges.