Histone demethylase KDM5D represses the proliferation, migration and invasion of hepatocellular carcinoma through the E2F1/TNNC1 axis.

Objective: This study focused on investigating the mechanism in which the KDM5D/E2F1/TNNC1 axis affected hepatocellular carcinoma (HCC) development.

Methods: At first, we determined HCC cell proliferation, migration, invasion, and apoptosis, as well as SOD activity, MDA content, and ROS level. ChIP assay was subsequently conducted to examine H3K4me3 modification in the E2F1 promoter region and the binding of E2F1 to the TNNC1 promoter region after KDM5D overexpression.

Too anthropomorphized to keep distance: The role of social psychological distance on meat inclinations.

Keeping a distance from food animals helps alleviate moral conflicts associated with meat consumption. Prior research on the 'meat paradox' has shown that physical distance from animals reduces negative emotional responses when consuming meat. However, even with physical distance, the presence of animals in meat advertisements and packaging can establish psychological contact.

MSCs-derived exosomes containing miR-486-5p attenuate cerebral ischemia and reperfusion (I/R) injury.

Objectives: This study aims to investigate the impact of mesenchymal stem cell (MSC)-derived exosomes (Exo) on cerebral ischemia and reperfusion (I/R) injury, along with the underlying mechanism.

Methods: An animal model of cerebral ischemia was induced using middle cerebral artery occlusion (MCAO), and a cell model utilizing Neuro-2a cells was established through oxygen-glucose deprivation/reoxygenation (OGD/R). Exosomes isolated from mouse MSCs were administered to mice or used to stimulate Neuro-2a cells.

Activation of Hypoxia Inducible Factor-1 Alpha-Mediated DNA Methylation Enzymes (DNMT3a and TET2) Under Hypoxic Conditions Regulates S100A6 Transcription to Promote Lung Cancer Cell Growth and Metastasis.

This research was aimed at investigating the effects of hypoxia inducible factor-1 alpha (HIF-1α)-mediated DNA methylation enzymes (ten-eleven translocase-2 [TET2] and DNA methyltransferase-3a [DNMT3a]) under hypoxic conditions on S100A6 transcription, thereby promoting the growth and metastasis of lung cancer cells. The expression of HIF-1α or S100A6 in lung cancer cells was interfered with under normoxic and hypoxic conditions, and the cell proliferative, migratory, and invasive properties were assessed. The mechanism of HIF-1α-regulated TET2 and DNMT3 effects on S100A6 transcription under hypoxic conditions was further investigated.

A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function.

Background: The study aims to explore the role of A1BG antisense RNA 1 (A1BG-AS1), microRNA (miR)-148a-3p and ubiquitin-specific protease 22 (USP22) on osteosarcoma (OS) cell growth.

Research Design & Methods: A1BG-AS1, miR-148a-3p, USP22, and silent information regulator 2 homolog 1 (SIRT1) levels in OS tissues and cells were determined. The effects of A1BG-AS1, miR-148a-3p, and USP22 on the biological functions of OS cells were examined by functional assays.

High Sensitivity and Wide Range Biomimetic Tactile-Pressure Sensor Based on 2D Graphene Film and 3D Graphene Foam.

Bionic electronic skin is a system that simulates human skin and has multiple perceptions. For pressure sensors, high measurement accuracy and wide measurement range restrict each other, and it is difficult to achieve high measurement accuracy and wide measurement range simultaneously. Therefore, the research and application of bionic tactile-pressure sensors are limited due to the mutual constraints of measurement accuracy and range.

CUX2/KDM5B/SOX17 Axis Affects the Occurrence and Development of Breast Cancer.

Objective: Abnormal expression of CUT-like homeobox 2 gene (CUX2) has been highlighted as potential clinical biomarkers in human cancers. Notably, the function of CUX2 has been less elucidated in breast cancer (BC). We focused on the role of the CUX2 in tumorigenesis and progression of BC with the involvement of the lysine demethylase 5B (KDM5B)/sex determining region Y-box 17 (SOX17) axis.

[Quality of realgar and its influencing factors based on toxicity].

The results of a toxicity analysis showed differences from those of the existing experimental data. Therefore, HPLC-ICP-MS was used to analyze the soluble arsenic content at different valences in realgar prepared with water grind processing, which were collected from 3 companies. The results showed that the free arsenic of the 3 companies did not exceed the limit of Chinese Pharmacopoeia.

Effects of Teriparatide, Denosumab, or Both on Spine Trabecular Microarchitecture in DATA-Switch: a Randomized Controlled Trial.

In postmenopausal women, 2 yr of combined teriparatide and denosumab increases bone mineral density more than either drug alone, and switching from either combination or teriparatide to denosumab for an additional 2 yr further increases bone mineral density. Conversely, switching from denosumab to teriparatide results in transient bone loss. The effects of these interventions on spine microarchitecture are unknown.

Importance of prompt antiresorptive therapy in postmenopausal women discontinuing teriparatide or denosumab: The Denosumab and Teriparatide Follow-up study (DATA-Follow-up).

When teriparatide and denosumab are discontinued, bone mineral density (BMD) abruptly decreases. To compare rates of bone loss in postmenopausal women who discontinue denosumab or teriparatide and receive no additional prescription osteoporosis medications to women who discontinue these drugs followed by prompt antiresorptive therapy, we asked women concluding the Denosumab and Teriparatide Administration (DATA) study and its extension, DATA-Switch, to return for BMD measurements 1-2years after study completion. In these studies, women received 2-years of either teriparatide, denosumab or both medications followed by 2-years of the alternate therapy (women who received combination therapy initially received an additional 2-years of denosumab alone).

Laser vibrometry from a moving ground vehicle.

We investigated the fundamental limits to the performance of a laser vibrometer that is mounted on a moving ground vehicle. The noise floor of a moving laser vibrometer consists of speckle noise, shot noise, and platform vibrations. We showed that speckle noise can be reduced by increasing the laser spot size and that the noise floor is dominated by shot noise at high frequencies (typically greater than a few kilohertz for our system).

Heterodyne detection with a weak local oscillator.

Heterodyne detection in the limit of weak (a few photons) local oscillator and signal power levels has been largely neglected in the past, as authors almost always assumed that the noise was dominated by the shot noise from a strong local oscillator. We present the theory for heterodyne detection of diffuse and specular targets at arbitrary power levels, including the case where the local oscillator power is only a few photons per coherent integration period. The theory was tested with experimental results, and was found to show good agreement.

Acquisition algorithm for direct-detection ladars with Geiger-mode avalanche photodiodes.

An optimal algorithm for detecting a target using a ladar system employing Geiger-mode avalanche photodiodes (GAPDs) is presented. The algorithm applies to any scenario where a ranging direct detection ladar is used to determine the presence of a target against a sky background within a specified range window. A complete statistical model of the detection process for GAPDs is presented, including GAPDs that are inactive for a fixed period of time each time they fire.

Photon statistics of amplified spontaneous emission noise in a 10-Gbit/s optically preamplified direct-detection receiver.

We verify experimentally, over a dynamic range of 55 dB in the probability distribution, that the amplified spontaneous emission noise of the 0's from an optically preamplified receiver is degenerate Bose-Einstein distributed. Using the noise parameters extracted from the experiment, we are able to predict the sensitivity of a 10-Gbit/s direct-detection receiver.

Timing restoration dynamics in an actively mode-locked fiber ring laser.

Using electronic phase detection, we study the dynamics that govern pulse retiming in an actively mode-locked fiber laser. We compare the dynamics for amplitude and for phase modulation and identify the characteristic time constants for each case. The retiming dynamics for amplitude modulation are revealed as a first-order exponential decay, whereas for phase modulation the dynamics are those of a damped harmonic oscillator.

Self-stabilized passive, harmonically mode-locked stretched-pulse erbium fiber ring laser.

We have studied a passive, harmonically mode-locked stretched-pulse erbium fiber ring laser with net positive dispersion that is self-stabilized by gain depletion and electrostriction. Periodic pulses with supermode suppression of >75 dB and picosecond jitter are achieved. The pulses are compressible to 125 fs by external chirp compensation.

Observation of quantum-limited timing jitter in an active, harmonically mode-locked fiber laser.

We report on the observation of quantum-limited timing jitter in a harmonically mode-locked soliton fiber laser with an ultralow-noise local oscillator. The effects of amplitude and phase modulation on the spectrum are described and compared with theory.

Quantum-limited noise performance of a mode-locked laser diode.

Low-noise operation of a 9-GHz hybridly mode-locked laser diode is demonstrated. The integrated timing jitter was 47 fs (10 Hz to 10 MHz) and 86 fs (10 Hz to 4.5 GHz), with a pulse width of 6.

Saturation effects in heterodyne detection with Geiger-mode InGaAs avalanche photodiode detector arrays.

We report, to the best of our knowledge, the first demonstration of heterodyne detection of a glint target using an InGaAs avalanche photodiode detector (APD) array in the Geiger mode. Due to the finite number of pixels, all such photon-counting arrays necessarily suffer from saturation effects. At large photon fluxes, saturation of the APD degrades the Doppler frequency resolution and the signal-to-noise ratio (SNR).

Ultralow-jitter, 1550-nm mode-locked semiconductor laser synchronized to a visible optical frequency standard.

Using high-bandwidth feedback, we have synchronized the pulse train from a mode-locked semiconductor laser to an external optical atomic clock signal and achieved what is to our knowledge the lowest timing jitter to date (22 fs, integrated from 1 Hz to 100 MHz) for such devices. The performance is limited by the intrinsic noise of the phase detector used for timing-jitter measurement. We expect such a highly stable device to play an important role in fiber-network-based precise time/frequency distribution.

Timing jitter eater for optical pulse trains.

Using a single phase modulator and dispersive fiber, we demonstrate a 12-dB reduction in the phase noise of a train of 6.5-ps pulses at a repetition rate of 10 GHz. A prechirp fiber is shown to improve performance.