Ruthenium eye plaque brachytherapy in the management of medium sized uveal melanoma.

Background: To evaluate Ruthenium Brachytherapy in management of medium sized uveal melanoma, with emphasis on 5-year outcome and toxicity.

Methods: From April 2007 to October 2015, 39 patients with medium sized uveal melanoma were treated with 106 Ru eye plaques brachytherapy. At the time of diagnosis, the mean tumor depth was 3.

Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes.

Purpose: Recurring keloids are a clinical challenge. Interdisciplinary treatments are required in most cases. Owing to the wide variety of concepts, the optimal treatment regime remains unclear.

Oligometastases in prostate cancer : Metabolic response in follow-up PSMA-PET-CTs after hypofractionated IGRT.

Background: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMAPET/CT) is a new and evolving diagnostic method in prostate cancer with special impact on treatment planning in image-guided radiotherapy (IGRT). Initial results of metabolic response in repeated PSMA PET/CTs after hypofractionated IGRT for metastatic lesions are reported here.

Materials And Methods: Of 280 patients investigated with Ga-PSMA PET/CT in the period from 01/2014 through 12/2016 in the authors' department, patients were selected according to the following criteria: oligometastatic disease at initial PSMA PET/CT defined as not more than five metastatic lesions, hypofractionated IGRT to all lesions, no systemic therapy in the last 6 months and during follow-up, and at least one follow-up PSMA PET after radiotherapy.

Interstitial high-dose-rate brachytherapy as salvage treatment for locally recurrent prostate cancer after definitive radiation therapy: Toxicity and 5-year outcome.

Purpose: We report our results with interstitial high-dose-rate brachytherapy (HDR-BT) as a salvage therapy option after external beam therapy with or without BT. Emphasis was put on toxicity and 5-year outcome.

Methods And Materials: From 2003 to 2011, 29 patients with local failure after previous radiotherapy for prostate cancer were treated with salvage interstitial HDR-BT.

New workflows and algorithms of bone scintigraphy based on SPECT-CT.

Gold standard bone scintigraphy workflow contains acquisition of planar anterior and posterior images and if necessary, additional SPECTs as well. Planar acquisitions are time consuming and not enough for accurately locating hotspots. Current paper proposes a novel workflow for fast whole body bone SPECT scintigraphy.

An extended registration framework for the triple registration of IBZM SPECT, DATSCAN SPECT and MRI brain images to support the evaluation of brain dopamine receptor scintigraphies.

An extended registration model is presented to register medical image triples acquired for brain dopamine receptor scintigraphies. The model operates with rigid and nonlinear transformations in parallel, where all transformation parameters are optimized by one optimization method. The concept of the transformation-sampling-similarity measurement minimizes the memory usage of a real implementation.

Automated lymph node detection and classification on breast and prostate cancer SPECT-CT images.

We present a novel detection and classification method to process SPECT-CT images representing breast and prostate lymph nodes. Lymph nodes are those nodes that are near the primer tumor and may become cancerous in time, hence their early detection is a key factor for the successful treatment of the patient. Prior methods focus on the visual aid to manually detect the lymph nodes which still makes the process time-consuming.