Metabolic Adaptation and Its Determinants in Adolescents Two Years After Sleeve Gastrectomy.

Weight loss is associated with reductions in resting energy expenditure (REE), which are impacted by changes in body composition following sleeve gastrectomy (SG). Current data regarding changes in measured REE (mREE) and metabolic adaptation in adolescents after SG are limited. We evaluated changes in mREE, metabolic adaptation, and body composition in youths after SG vs.

Application of Reverse Sural Flaps in Pediatric Patients: A Systematic Review.

Introduction: The reverse sural flap (RSF) is a random-type, pedicled flap based on sural artery perforators indicated for traumatic lower-extremity wounds. The RSF has demonstrated comparable results to free flap placement in the adult population for reconstruction of distal third defects, but few reports describe its application and outcomes in the pediatric population.

Methods: We investigated RSF application in pediatric patients (<18 years of age) through systematic review and meta-analysis.

Diagnostic modalities in the mediastinum and the role of bronchoscopy in mediastinal assessment: a narrative review.

Background And Objective: Diagnosis of pathology in the mediastinum has proven quite challenging, given the wide variability of both benign and malignant diseases that affect a diverse array of structures. This complexity has led to the development of many different non-invasive and invasive diagnostic modalities. Historically, diagnosis of the mediastinum has relied on different imaging modalities such as chest X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission topography.

Quantification of Minerals in Edible Mushrooms via Optimized Microwave-Assisted Digestion: Nutritional Contributions of Fe, Mg, Na, K, and Ca.

The intake of mushrooms provides numerous beneficial properties for the correct functioning of the human body due to their rich content in carbohydrates, proteins, fibers, vitamins, and minerals. However, most of the reports are focused on the determination of bioactive compounds and only a few regarding the essential mineral content and the evaluation of the RDI. Thus, the aim of this study was to determine the mineral composition of different cultivated ( and ) and wild edible mushrooms (, , , , , and ) collected in the south of Spain and north of Morocco.

Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence.

Early Life Adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized to buffer the detrimental effects of ELA on child development, its role in mitigating epigenetic age acceleration remains unclear. Data from 2,039 children (49.

Advantages of the standardized use of preoperative fascia iliaca block versus conventional analgesia in older adults with fragility hip fracture: A retrospective cohort study at two hospitals in Colombia.

Hospital admission due to fragility hip fracture has increased significantly in recent years. In patients with hip fracture, perioperative pain management is usually with opioids, whose dosage is difficult to adjust and have many side effects, especially in older adults. The purpose of this study was to determine the impact and the advantages of the implementation of the fascia iliaca blockade in older adults with hip fracture due to fragility included in the Orthogeriatric Clinical Care Center of the Fundación Santa Fe de Bogotá and the San José Infantil University Hospital in Bogotá, Colombia.

Impact of dietary supplementation of L-citrulline to meat goats during gestation on reproductive performance.

Background: Meat goat production is a worldwide industry with products such as meat, milk, soap, and fiber being produced. There are approximately 2.6 million meat goats in the United States.

The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities.

Cytokines are small proteins that are critical for controlling the growth and activity of hematopoietic cells by binding to cell surface receptors and transmitting signals across membranes. The β common (βc) cytokine receptor family, consisting of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 cytokine receptors, is an architype of the heterodimeric cytokine receptor systems. We now know that signaling by cytokine receptors is not always an "all or none" phenomenon.

Promotora intervention for metabolic and mental health to reduce type 2 diabetes risk: a pilot randomized controlled trial.

The objective of this study was to develop and evaluate a novel behavioral intervention (PRIME2) that integrates evidence-based approaches for reducing diabetes risk and perceived stress. We conducted a pilot randomized controlled trial of the 16-session PRIME2 intervention vs. usual care among 40 Spanish-speaking Latinx adults with prediabetes and body mass index (BMI) ≥ 25 kg/m.

Comprehensive air quality assessment including non-targeted approaches in primary schools from Spain.

This work aims to establish a strategy to comprehensively assess the indoor air quality in schools including the analysis of chemical pollutants, bio-aerosols like fungi, bacteria and respiratory viruses and the identification of volatile and semi-volatile organic compounds applying non-targeted approaches. For this, a pilot study was performed in four primary schools from Spain, located in different urban and rural areas during different seasons. Common indoor pollutants, like CO NO, O, CO, particulate matter (PM, PM), ultrafine particles (UFP), total volatile organic compounds (TVOCs), and formaldehyde (HCHO), were assessed in terms of maximum recommended levels, daily variations, seasonality, and school location.

Generation of induced pluripotent stem cell lines TRNDi037-A and TRNDi038-A from two patients with Alagille syndrome carrying heterozygous JAG1 mutations.

Human induced pluripotent stem cell (iPSC) lines TRNDi037-A and TRNDi038-A were generated from the lymphoblastoid cell lines (LCL) of two patients with different heterozygous JAG1 variants resulting in Alagille syndrome (ALGS). ALGS is a rare genetic disease of haploinsufficiency that affects the formation of the bile duct, in addition to other symptoms. These ALGS iPSC lines can be used to model ALGS and aid in the identification of therapeutics to treat patients with ALGS.

Intraoperative Molecular Imaging With Pafolacianine: Histologic Characteristics of Identified Nodules.

Background: With increased early detection efforts, surgery for early-stage lung cancer is expected to rise. Pafolacianine is the first FDA approved targeted optical imaging agent indicated as an adjunct for intraoperative identification of malignant and nonmalignant pulmonary lesions in adult patients with known or suspected cancer in the lung.

Methods: This is a retrospective review of the malignant and nonmalignant lesions identified by pafolacianine with intraoperative molecular imaging (IMI) in the multi-center Phase 2 and Phase 3 ELUCIDATE clinical trials.

Optical coherence tomography enables longitudinal evaluation of cell graft-directed remodeling in stroke lesions.

Stem cell grafting can promote glial repair of adult stroke injuries during the subacute wound healing phase, but graft survival and glial repair outcomes are perturbed by lesion severity and mode of injury. To better understand how stroke lesion environments alter the functions of cell grafts, we employed optical coherence tomography (OCT) to longitudinally image mouse cortical photothrombotic ischemic strokes treated with allogeneic neural progenitor cell (NPC) grafts. OCT angiography, signal intensity, and signal decay resulting from optical scattering were assessed at multiple timepoints across two weeks in mice receiving an NPC graft or an injection of saline at two days after stroke.

Outcome Analysis of Parathyroid Gland Auto-transplantation in Pediatric Patients: A Retrospective Review.

Parathyroid gland (PG) auto-transplantation is performed to preserve the function of de-vascularized or unintentionally removed PGs, however, little has been published about the technique and outcomes in children. In our study, we aimed to present the results of PG auto-transplantation in children undergoing thyroidectomy or parathyroidectomy at a tertiary single institution. A retrospective review identified 14 patients (<18 years of age) who underwent PG auto-transplantation from January 2000 to December 2022.

Patient-reported functional outcomes and treatment-related regret in Hispanic and Spanish-speaking men following prostate cancer treatment.

Objectives: Compare functional outcomes and treatment-related regret over 10 years in Spanish- and English-speaking Hispanic men compared to non-Hispanic men following treatment of localized prostate cancer.

Methods And Materials: Data from a prospective cohort study of men with localized prostate cancer treated with active surveillance, radical prostatectomy or radiotherapy were used to examine the effect of survey language (Spanish speaking vs. English speaking) and ethnicity (Hispanic vs.

Predicting the drift of small cetaceans stranded along the Atlantic coast of the Iberian Peninsula: Parametrization of the MOTHY drift model.

Marine mammal populations, particularly the common dolphin Delphinus delphis in the North-East Atlantic, play an essential role as indicators of ecosystem health. Effective monitoring of these populations is essential for assessing anthropogenic impacts, especially in the context of current threats such as fisheries bycatch. The MOTHY drift model, initially designed for oil spills and then adapted to carcass drift, is being used in part of the North East Atlantic (Bay of Biscay, English Chanel, and North Sea) to estimate the bycatch mortality of common dolphins.

New Insights on the Diversity, Ecology and Genetic Population Structure of spp. from Fish and Cetacean Hosts from Northeast Atlantic Waters.

In the last 25 years, nematode parasites of the genus have attracted international attention from various socio-economic sectors, with serious concern about the impact of these parasites on seafood quality and safety, and public health (related to both zoonoses and allergy). A knowledge-based understanding of the population structure of spp. is useful to provide valuable data about the infection dynamics, host specificity and its ability to adapt to local environments and to climate change by adapting to the food-web structure.

Women faculty members' challenges when pursuing leadership positions in academic dentistry: A survey.

Purpose/objectives: This study addresses persistent gender disparities in leadership roles in academic dentistry. The objectives were to identify the challenges and barriers to leadership that women face in general and during the COVID-19 pandemic, as well as to describe resources they need to reach their leadership potential.

Methods: The American Dental Education Association Section on Women in Leadership (WIL), gathered survey data concerning leadership challenges and faculty development needs.

Unanticipated Economic Burden of Cosmetic Surgery Tourism: A Single Academic Center's Experience.

Introduction: Cosmetic surgery tourism is a burgeoning field, attracting patients with the possibility of procedures at reduced costs. Patients are often unaware of the potential cost of managing complications, with the cost often passed on to the local healthcare systems. We report our experience at a single academic center which serves as a safety net hospital managing cosmetic surgery tourism patients.

Phosphoproteomics analyses of fat body reveals blood meal-induced signaling and metabolic pathways.

The mosquito fat body is the principal source of yolk protein precursors (YPP) during mosquito egg development in female . To better understand the metabolic and signaling pathways involved in mosquito reproduction, we investigated changes in the mosquito fat body phosphoproteome at multiple time points after a blood meal. Using LC/MS, we identified 3570 phosphorylated proteins containing 14,551 individual phosphorylation sites.