Cutting-Edge Therapy and Immune Escape Mechanisms in EBV-Associated Tumors.

Epstein-Barr virus (EBV), the first identified human tumor virus, significantly influences the immune microenvironment of associated cancers. EBV-induced expression of viral antigens by tumor cells triggers immune recognition and elicits a pro-inflammatory response. While mild inflammation may help eliminate malignant cells, intense inflammation can accelerate tumor progression.

The Complete Chloroplast Genome and the Phylogenetic Analysis of (Cyperaceae) Collected in Cherry Blossom Nursery.

, also known as globe fringerush, is one of the most troublesome annual Cyperaceae weeds in dryland fields and nurseries in the Yangtze Plain, Middle and Lower in China. The chloroplast (cp) genome of , and even this genus, has not been studied yet. In this study, the feature of the cp genome of and its phylogenetic relationships has been reported for the first time.

Repetitive Low-Level Blast Exposure Alters Circulating Myeloperoxidase, Matrix Metalloproteinases, and Neurovascular Endothelial Molecules in Experienced Military Breachers.

Repeated exposure to low-level blast overpressure, frequently experienced during explosive breaching and heavy weapons use in training and operations, is increasingly recognised as a serious risk to the neurological health of military personnel. Although research on the underlying pathobiological mechanisms in humans remains limited, this study investigated the effects of such exposure on circulating molecular biomarkers associated with inflammation, neurovascular damage, and endothelial injury. Blood samples from military breachers were analysed for myeloperoxidase (MPO), matrix metalloproteinases (MMPs), and junctional proteins indicative of blood-brain barrier (BBB) disruption and endothelial damage, including occludin (OCLN), zonula occludens-1 (ZO-1), aquaporin-4 (AQP4), and syndecan-1 (SD-1).

Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse.

Background: Gelsemium elegans (G. elegans) is widely recognized as one of the most toxic plants globally, particularly harmful to humans. Some reports indicate that it is non-toxic to pigs and even has a growth-promoting effect; however, the underlying reasons for this paradox remain unclear.

Rapidly separable bubble microneedle-patch system present superior transdermal mRNA delivery efficiency.

Traditional mRNA vaccine formulation loaded by lipid nanoparticle (mRNA-LNP) has several shortcomings in clinical application, including the need for cryopreservation, discomfort associated with intramuscular injections, and the risk of liver aggregation. Dissolvable microneedles (DMNs), as a novel transdermal drug delivery platform, can overcome the skin barrier to deliver drugs directly into the skin in a minimally invasive manner. However, mRNA-LNP is unstable and easily degraded during the solidification of DMN.

Phase Change-Mediated Capture of Carbon Dioxide from Air with a Molecular Triamine Network Solid.

The efficient removal of CO from exhaust streams and even directly from air is necessary to forestall climate change, lending urgency to the search for new materials that can rapidly capture CO at high capacity. The recent discovery that diamine-appended metal-organic frameworks can exhibit cooperative CO uptake via the formation of ammonium carbamate chains begs the question of whether simple organic polyamine molecules could be designed to achieve a similar switch-like behavior with even higher separation capacities. Here, we present a solid molecular triamine, 1,3,5-tris(aminomethyl)benzene (TriH), that rapidly captures large quantities of CO upon exposure to humid air to form the porous, crystalline, ammonium carbamate network solid TriH(CO)·HO (TriHCO).

Challenges and Opportunities in Implementing a Multicomponent Dementia Caregiver Program in a Complex Healthcare System.

The Tailored Activity Program (TAP), an intervention for people living with dementia (PLWD) and their caregivers, has been shown to reduce behavioral symptoms for PLWD and caregiver burden. While TAP is proven as an evidence-based practice (EBP), it has yet to be implemented at scale. The Department of Veterans Affairs (VA) has prioritized the Age-Friendly Health System (AFHS) initiative, providing an opportunity to test implementation of TAP in a complex healthcare system.

A new data-driven paradigm for the study of avian migratory navigation.

Avian navigation has fascinated researchers for many years. Yet, despite a vast amount of literature on the topic it remains a mystery how birds are able to find their way across long distances while relying only on cues available locally and reacting to those cues on the fly. Navigation is multi-modal, in that birds may use different cues at different times as a response to environmental conditions they find themselves in.

Post-Movement Beta Synchronization Induced by Speed Effects IHI from Ipsilateral to Contralateral Motor Cortex.

Beta event-related spectral perturbation (ERSP), including bilateral movement-related beta desynchronization (MRBD) and post-movement beta synchronization (PMBS), can be evoked by unilateral speed movement. A potential correlation might exist between power (de)synchronization and interhemispheric coherence during movement execution. However, during the PMBS phase, the existence of interhemispheric coupling and the effect of speed on it are largely undiscovered.

The effects of a salutogenic strength-based intervention on sense of coherence and health outcomes in newly diagnosed HIV-positive MSM: A randomized controlled trial.

Background: Newly diagnosed HIV-positive men who have sex with men (MSM) often face significant psychological stress, resulting in a high prevalence of issues such as anxiety and depression. Sense of coherence, an internal strength factor, is known to offer protective effect against health challenges. However, interventions specifically designed to enhance sense of coherence in this population remain limited.

A Novel Approach for Suprachoroidal Space Injection: An Experimental Evaluation.

Purpose: This study aims to describe an innovative suprachoroidal space injection technique using a combination of 30 G and 22 G needles attached to a 1 ml injector. The efficacy and applicability of this technique in suprachoroidal injections are evaluated.

Methods: In this study, we conducted both and injection experiments using isolated porcine eyes and live SD rats, respectively.

Design and Rationale for the Clinical Investigation of a Novel, Magnetically Levitated Left Ventricular Assist Device for the Treatment of Refractory Heart Failure.

Background: Contemporary durable left ventricular assist devices (LVAD) have established current benchmarks for patient outcomes, but introduction of more novel technology is lacking. The BrioVAD System (BrioHealth Solutions, Burlington, MA) is an innovative, fully magnetically levitated pump intended to provide short-term (ST) and long-term (LT) mechanical circulatory support.

Methods: The Investigation of a Novel, MagNetically Levitated VAD for the Treatment of RefractOry Left Ventricular HeArT FailurE Clinical Trial (INNOVATE) is designed to evaluate safety and efficacy of the BrioVAD by demonstrating non-inferiority to the HeartMate 3 (HM3; Abbott Labs, Chicago, IL).

The SUbventral-Gland Regulator (SUGR-1) of nematode virulence.

Pathogens must precisely tailor their gene expression to cause infection. However, a signaling cascade from host signal to effector production has remained elusive for metazoan pathogens. Here, we show that plants contain molecular signals, termed effectostimulins, that activate the first identified regulator of plant-parasitic nematode effectors.

A rule- and query-guided reinforcement learning for extrapolation reasoning in temporal knowledge graphs.

Extrapolation reasoning in temporal knowledge graphs (TKGs) aims at predicting future facts based on historical data, and finds extensive application in diverse real-world scenarios. Existing TKG reasoning methods primarily focus on capturing the fact evolution to improve entity temporal representations, often overlooking the alignment with query semantics. More importantly, these methods fail to generate explicit inference paths, resulting in a lack of explainability.

What factors predict ambulance prealerts to the emergency department? Retrospective observational study from three UK ambulance services.

Objectives: Ambulance clinicians use prealert calls to advise emergency departments (ED) of the arrival of patients requiring immediate review or intervention. Consistency of prealert practice is important in ensuring appropriate ED response to prealert calls. We used routine data to describe prealert practice and explore factors affecting variation in practice.

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation.

Compared with the well-established functions of sympathetic innervation, the role of sensory afferents in adipose tissues remains less understood. Recent work has revealed the anatomical and physiological significance of adipose sensory innervation; however, its molecular underpinning remains unclear. Here, using organ-targeted single-cell RNA sequencing, we identified the mechanoreceptor PIEZO2 as one of the most prevalent receptors in fat-innervating dorsal root ganglia (DRG) neurons.

Two inflammation-related genes model could predict risk in prognosis of patients with lung adenocarcinoma.

Background: In lung adenocarcinoma (LUAD), there remains a dearth of efficacious diagnostic studies including some inflammation-related genes to identify the LUAD subgroups with different clinical outcomes.

Methods: First, two molecular subgroups were identified with mRNA expression profiling from The Cancer Genome Atlas (TCGA) by K-means algorithm. Gene set enrichment analysis (GSEA), immune infiltration, and Gene set variation analysis (GSVA) were applied to explore the biological functions between these two subtypes.

A facile approach for synthesizing nitrogen-doped carbon supported circular trough-shaped FeCo alloy for the oxygen reduction reaction.

A nitrogen-doped carbon-supported circular trough-shaped FeCo alloy-based electrocatalyst (FeCo/NC) was synthesized by a simple-to-accomplish method. The unique alloy structure and rich Fe/Co-N-based active sites constructed during the pyrolysis process endowed FeCo/NC with comparable electrocatalytic ORR activity in both a three-electrode system and Zn-air batteries to that of previously reported FeCo alloy-based catalysts.

Subcutaneous zilucoplan: evaluation of reproductive toxicology.

To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and postnatal development (ePPND) study. Human transplacental transfer of zilucoplan was examined in an ex vivo human placental perfusion model of foetal exposure during pregnancy. By comparison with the positive control, a low transfer rate of 0.

Deconvolving lithium-ion redox in vanadium-iron oxide aerogels using X-ray absorption spectroscopy and density functional theory.

Substitution of vanadium into earth-abundant maghemite iron oxide introduces cation vacancies that increase Li storage capacity concomitant with a positive shift in its electrochemical potential. Expressing vanadium ferrite (VFeO) as an aerogel offers an opportunity to probe Li storage in this inherently defective spinel from highly disordered (X-ray amorphous) to nanocrystalline. To understand the redox sequence of the host cations, we use X-ray absorption near-edge spectroscopy (XANES) obtained using an in-lab X-ray absorption spectrometer in concert with density functional theory calculations to uncover the quantum mechanical-level effects that underpin relevant energy-storage behaviors.

Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study.

Background: Cognitive impairment is a common dysfunction following stroke, significantly affecting patients' quality of life. Studies suggest that post-stroke cognitive impairment (PSCI) may be related to neural activity in specific brain regions. However, the neural mechanisms remain to be further explored.

Submental Microneedles of Botulinum Toxin A for Double Chin After Neck Injection.

Neck injections of botulinum toxin A (BTX-A) are an effective, minimally invasive approach to improve lower face sagging, especially in Asian populations. However, cases of worsened "double chin" have been observed postinjection, likely due to the platysma muscle type and limited anterior neck injection range, which may result in compensatory platysma contraction. Five female patients who developed aggravated double chin after BTX-A injections in the lower jaw and neck were treated with microneedle BTX-A injections (10-20 U in 3-4 rows with 0.

High-dose radiation induces dendritic cells maturation by promoting immunogenic cell death in nasopharyngeal carcinoma.

Aim And Background: Due to the radiosensitivity and deep anatomical location of nasopharyngeal carcinoma (NPC), radiotherapy serves as the cornerstone of standardized treatment for this malignancy. Beyond its cytotoxic effects, radiotherapy can serve as an immunological adjuvant by inducing immunogenic cell death (ICD). Dendritic cells (DCs), as potent antigen-presenting cells, play a critical role in tumor immunotherapy, but their exact role in the ICD process of NPC remains unclear.