Associations between modifiable risk factors and cognitive function in middle-aged and older Chinese adults: joint modelling of longitudinal and survival data.

Background: Stronger associations between modifiable risk factors and cognitive function have been found in younger than older adults. This age pattern may be subject to mortality selection and non-ignorable missingness caused by dropouts due to death, but this remains unclear.

Methods: Longitudinal data from 9,562 adults aged 50 and older from Waves 1-4 (2011-2018) of the China Health and Retirement Longitudinal Study were used.

A deep learning model for predicting the modified micro-dosimetric kinetic model-based dose and the dose-averaged linear energy transfer for prostate cancer in carbon ion therapy.

Adaptive carbon ion radiotherapy for localized prostate cancer requires accurate evaluation of biological dose and dose-averaged linear energy transfer (LET) changes. This study developed a deep learning model to rapidly predict the modified micro-dosimetric kinetic model (mMKM)-based dose and LET distributions. Using data from fifty patients for training and testing, the model achieved gamma passing rates exceeding 96% compared to true mMKM-based dose and LET recalculated from local effect model I (LEM I) plans.

Global differences and risk factors influencing drug hypersensitivity quality of life: A multicenter, multiethnic study of drug allergy across 3 continents.

Background: Penicillin allergy labels are associated with many adverse outcomes. Fear and restriction of future medication use also have an impact on health-related quality of life (HR-QoL). However, the impact of a drug allergy on HR-QoL and its associated factors remains unknown.

Halogen bonding accelerated aerobic dehydrogenative aromatization for 4-aminoquinoline preparation.

This study presents a highly efficient method for 4-aminoquinoline derivative preparation under transition metal-free conditions. The process involves an aerobic oxidative dehydrative coupling of 2,3-dihydroquinolin-4(1)-ones with various amines, including ammonia, resulting in high yields of the desired products. The method is also applicable to substituted 4-aminoquinoline derivative construction through a cyclization/dehydrative coupling cascade process starting from 2'-amino chalcones.

Shifts in Plant Phenology Significantly Affect the Carbon Allocation in Different Plant Organs.

Earlier start of the growing season (SGS) and delayed end of the growing season (EGS) affect plant carbon uptake. However, the effects of phenological changes on carbon allocation to different plant organs remain unclear. Here, we examined the effects and potential mechanisms of phenological changes on carbon allocation to different organs over the northern hemisphere (> 30° N).

Preoperative Analgesia Efficacy of Liposomal Bupivacaine Following Pericapsular Nerve Group (PENG) Block in Patients with Hip Fracture: A Randomized Controlled Observer-Blinded Study.

Introduction: Single-injection pericapsular nerve group (PENG) block with ropivacaine provides clear analgesic effects in preoperative pain management for hip fractures. However, it suffers from insufficient duration, failing to meet the needs of most patients. This single-center, randomized controlled, observer-blinded trial utilizes a novel combination of liposomal bupivacaine (LB) single-injection PENG block to examine its efficacy, duration, and safety in preoperative analgesia for hip fractures, aiming to develop a new preoperative analgesic protocol.

Characterization of a Putative Lysin from Enterococcus faecalis Phage IME-EFm1 and Determination of its Protective Efficacy in Mice.

The rising tide of bacterial drug resistance has sparked renewed interest in bacteriophages, the natural predators of bacteria. Our study highlights IME-EFm1, a Caudoviricetes bacteriophage specifically targeting Enterococcus faecium. Through our investigations, we identified that the gene IME-EFm1-ORF24 encodes an amidase, referred to as gp24, with promising lytic capabilities.

Associations between serum potassium variability and mortality in patients undergoing maintenance hemodialysis: a retrospective study.

Dyskalemia are associated with an increased risk of mortality in patients undergoing maintenance hemodialysis (MHD). However, studies evaluating the impact of serum potassium variability on mortality in MHD patients are scarce. To investigate serum potassium variability and its association with prognosis in MHD patients, we conducted a retrospective study on maintenance hemodialysis patients from three campus of Renji Hospital between June 2018 and December 2022.

[The value of WT1 mRNA expression level in the diagnosis and prognosis evaluation of myelodysplastic syndromes].

To analyze the value of the WT1 mRNA expression level in the diagnosis and prognostic evaluation of myelodysplastic syndrome (MDS) . A total of 403 patients with MDS, suspected MDS, and acute myeloid leukemia secondary to MDS (AML-MDS) from eight clinical trial centers in China were included in this multicenter, prospective study. Nucleic acid was extracted from the peripheral blood (PB) and bone marrow (BM) samples and WT1 mRNA expression was measured using the WT1 mRNA assay kit.

Engineered Reactive Oxygen Species (ROS)-Responsive Artificial H/Cl Ion Channels for Targeted Cancer Treatment.

Reactive oxygen species (ROS)-responsive ion channels regulate the ion flow across the membranes in response to alterations in the cellular redox state, playing a crucial role in cellular adaptation to oxidative stress. Despite their significance, replicating ROS-responsive functionality in artificial ion channels remains elusive. In this study, we introduce a novel class of artificial H/Cl ion channels activatable by elevated ROS levels in cancer cells.

HO accumulation promoting internalization of ox-LDL in early atherosclerosis revealed a synergistic dual-functional NIR fluorescence probe.

The equilibrium of lipid metabolism is critical to sustaining human health. Metabolic disorders often result in a variety of cardiovascular illnesses, especially atherosclerosis. Atherosclerosis is characterized by complicated complications and high mortality.

Prevalence and Impact of Fractures in Persons with Spinal Cord Injuries: A Population-Based Study Comparing Fracture Rates between Individuals with Traumatic and Nontraumatic Spinal Cord Injury.

Background: Musculoskeletal complications are one of the most common reasons for a patient with a spinal cord injury (SCI) to be rehospitalized. Bone loss due to immobilization and changes in metabolic processes because of the SCI lead to an increased risk of fractures.

Objective: To evaluate the prevalence and demographic characteristics of people living with an SCI who had a secondary fracture.

(Gesneriaceae), a New Species From Southwestern Guangxi, China.

The genus is renowned for its remarkably diverse floral morphology, exhibiting a high level of disparity compared to most genera within Gesneriaceae. In this study, we present a detailed description and illustration of T. Ding & B.

Characterisation of kefir-derived lactic acid bacteria and their extracellular vesicles.

The signalling effects of microbial biofilms and extracellular polysaccharides (EPS) determine the stability of microbial communities. As messenger molecules, extracellular vesicles (EVs) mediate the interactions of microbial populations by carrying cargo. Therefore, this study took biofilm and EPS as screening factors, preliminarily explored the basic characteristics of strains with strong biofilm formation ability and high EPS production.

Spatiotemporal prediction of alpine wetlands under multi-climate scenarios in the west of Sichuan, China.

Background: The alpine wetlands in western Sichuan are distributed along the eastern section of the Qinghai-Tibet Plateau (QTP), where the ecological environment is fragile and highly sensitive to global climate change. These wetlands are already experiencing severe ecological and environmental issues, such as drought, retrogressive succession, and desertification. However, due to the limitations of computational models, previous studies have been unable to adequately understand the spatiotemporal change trends of these alpine wetlands.

LMAN2 Promotes Breast Cancer Tumorigenesis and Drug Resistance by Interacting With MAPK9 via Activation of the MAPK Pathway.

Introduction: Breast cancer (BC) is the most prevalent malignancy among women worldwide. Lectin, mannose-binding 2 (LMAN2) is a cargo receptor engaged in the transport and sorting of glycoproteins. Despite its ubiquity, the function and underlying mechanisms of LMAN2 in BC continue to elude understanding.

Identification of polyamine metabolism-related prognostic biomarkers for predicting breast cancer prognosis, immune microenvironment, and candidate drugs.

In this study, polyamine metabolism related genes (PMRGs) were used to establish a breast cancer (BC) prognostic model. Using PMRGs, TCGA BC samples were divided into cluster1 and cluster2. A 13-gene BC prognostic model was constructed by screening differential genes.

Rapid Characterization of the Constituents in Shenhua Tablets by UHPLC-Q-Orbitrap-LTQ-MS.

Shenhua Tablet (SHT), a Chinese herbal medicine comprising seven crude drugs, is utilized in the treatment of immunoglobulin A nephropathy (IgAN). However, due to its complex composition, the chemical constituents of SHT in vitro are still incompletely known, which has restricted the comprehensive development and utilization of SHT in clinical practice. In the present study based on ultra-high performance liquid chromatography-quadrupole-orbitrap-linear ion trap mass spectrometry (UHPLC-Q-Orbitrap-LTQ-MS) in data dependent acquisition mode, combining the accurate mass and structural information, the profiling and characterization of chemical constituents in SHT were carried out.

GI cancer mortality in participants in low dose CT screening for lung cancer with a focus on pancreatic cancer.

Lung cancer, the leading cause of cancer deaths globally, has better survival rates with early detection. Annual low-dose CT (LDCT) screenings are recommended for high-risk individuals due to age and smoking. These individuals are also at risk for other cancers.

Therapeutic potential of interleukin-17 neutralization in a novel humanized mouse model of Sjögren's disease.

Sjögren's disease (SjD) is a chronic autoimmune disease, in which the immune system targets exocrine glands and leads to dryness symptoms. There is an increasing need to develop novel therapeutic approach as the treatment plan has not been changed in the past decade. However, findings in mouse model may not be directly applied in patients, given the substantial differences of immune system between human and mice.