Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches.

Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests.

The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex.

The human cerebral cortex is one of the most evolved regions of the brain, responsible for most higher-order neural functions. Since nerve cells (together with synapses) are the processing units underlying cortical physiology and morphology, we studied how the human neocortex is composed regarding the number of cells as a function of sex and age. We used the isotropic fractionator for cell quantification of immunocytochemically labeled nuclei from the cerebral cortex donated by 43 cognitively healthy subjects aged 25-87 years old.

SemClinBr - a multi-institutional and multi-specialty semantically annotated corpus for Portuguese clinical NLP tasks.

Background: The high volume of research focusing on extracting patient information from electronic health records (EHRs) has led to an increase in the demand for annotated corpora, which are a precious resource for both the development and evaluation of natural language processing (NLP) algorithms. The absence of a multipurpose clinical corpus outside the scope of the English language, especially in Brazilian Portuguese, is glaring and severely impacts scientific progress in the biomedical NLP field.

Methods: In this study, a semantically annotated corpus was developed using clinical text from multiple medical specialties, document types, and institutions.

An Ultrasonic-Capacitive System for Online Characterization of Fuel Oils in Thermal Power Plants.

This paper presents a ultrasonic-capacitive system for online analysis of the quality of fuel oils (FO), which are widely used to produce electric energy in Thermal Power Plants (TPP) due to their elevated heating value. The heating value, in turn, is linked to the quality of the fuel (i.e.

Automatic chronic degenerative diseases identification using enteric nervous system images.

Studies recently accomplished on the Enteric Nervous System have shown that chronic degenerative diseases affect the Enteric Glial Cells (EGC) and, thus, the development of recognition methods able to identify whether or not the EGC are affected by these type of diseases may be helpful in its diagnoses. In this work, we propose the use of pattern recognition and machine learning techniques to evaluate if a given animal EGC image was obtained from a healthy individual or one affect by a chronic degenerative disease. In the proposed approach, we have performed the classification task with handcrafted features and deep learning-based techniques, also known as non-handcrafted features.

Effect of myofascial release on lower limb range of motion, sit and reach and horizontal jump distance in male university students.

Objective: Evaluate the effects of Myofascial release (MR) on lower limb ROM, sit and reach and horizontal jump distance in male university students.

Study Design: Quasi-experimental study.

Background: MR is a technique that aims to stretch fascia to increase range of motion (ROM), relieve pressure points and improve performance.

Systolic dysfunction by two-dimensional speckle tracking echocardiography in dogs with parvoviral enteritis.

Introduction/objectives: Parvoviral enteritis (PVE) can cause either primary or secondary myocardial injury; the latter is associated with systemic inflammatory response syndrome and sepsis. Strain (St) and strain rate (SR) are relatively new speckle tracking echocardiographic (STE) variables used to assess myocardial function and are less influenced by preload and volume status than are conventional variables. The aim of this study was to evaluate systolic function in dogs with PVE using two-dimensional STE.

Latex proteins from Plumeria pudica reduce ligature-induced periodontitis in rats.

Background: Previous studies have shown that latex proteins from Plumeria pudica (LPPp) have anti-inflammatory and antioxidant activity. Therefore, the aim of this study was to evaluate the effects in rats of LPPp on ligature-induced periodontitis, an inflammatory disease.

Methods: The animals were divided into groups: saline (animals without induction of periodontitis), periodontitis (induced periodontitis and untreated) and LPPp (induced periodontitis and treated with 40 mg/kg).

Acid mine drainage at the Bahia Gold Belt (Brazil): microbial isolation and characterization.

Acid mine drainage occurs due to the chemical and microbiological oxidation of sulfide minerals and can be a source of potentially toxic elements contamination of groundwater and surface water. The objective of this study was to identify microorganisms involved in sulfide oxidation in the tailings of a Bahia Gold Belt mine (Brazil). Samples of solids and water were collected at the mine tailings dam and characterized.

EFFECTS OF BLOOD FLOW RESTRICTION TRAINING ON HANDGRIP STRENGTH AND MUSCULAR VOLUME OF YOUNG WOMEN.

Background: High-intensity training methods are generally recommended to increase muscle mass and strength, with training loads of 60-70% 1RM for novice and 80-100% 1RM for advanced individuals. Blood flow restriction training, despite using lower intensities (30-50% 1RM), can provide similar improvements in muscle mass and strength. However, studies commonly investigate the effects of blood flow restriction training in large muscular groups, whereas there are few studies that investigated those effects in smaller muscle groups, such as the muscles involved in grasping (e.

Direct and residual effect of biochar derived from biosolids on soil phosphorus pools: A four-year field assessment.

Measures to improve the use of phosphorus (P), either by improved efficiency or reuse, are needed worldwide in order to preserve a finite resource and ensure that farmers have access to it. Currently, the rapidly growing global population has generated an increased demand for this mineral. Sustainably disposing for the massive amount of globally produced biosolids and alternative sources of P for agriculture are two major challenges to address.

Reduced bioavailability of oral amoxicillin tablets compared to suspensions in Roux-en-Y gastric bypass bariatric subjects.

Aims: To evaluate the relative bioavailability of oral amoxicillin (AMX) tablets in comparison to AMX suspension in Roux-en-Y gastric bypass bariatric subjects.

Methods: A randomized, double-blind, cross-over study was performed on the bioavailability of oral AMX tablets and suspension in Roux-en-Y gastric bypass subjects operated at least 3 months previously . Doses of 875 mg of the AMX tablet or 800 mg of the AMX suspension were given to all the subjects, allowing a washout of 7 days between the periods.

Proteins from Plumeria pudica latex exhibit protective effect in acetic acid induced colitis in mice by inhibition of pro-inflammatory mechanisms and oxidative stress.

Latex proteins from P. pudica (LPPp) have anti-inflammatory activity. In the present study, LPPp was evaluated to protect animals against inflammatory ulcerative colitis (UC).

Antidiarrheal effects of water-soluble proteins from Plumeria pudica latex in mice.

The water-soluble protein fraction obtained from Plumeria pudica (LPPp) latex has previously been demonstrated to have anti-inflammatory and antinociceptive effects. In the present study, LPPp was tested for activity against diarrhea induced by castor oil, prostaglandin E (PGE) or cholera toxin. Different doses of LPPp (10, 20 or 40mg/kg) significantly inhibited the percentage of diarrheal stools (31.

Chemical analysis and biorefinery of red algae Kappaphycus alvarezii for efficient production of glucose from residue of carrageenan extraction process.

Background: Biorefineries serve to efficiently utilize biomass and their by-products. Algal biorefineries are designed to generate bioproducts for commercial use. Due to the high carbohydrate content of algal biomass, biorefinery to generate biofuels, such as bioethanol, is of great interest.

Comparative anatomy of the extraocular muscles in four Myliobatoidei rays (Batoidea, Myliobatiformes).

Extraocular muscles are classically grouped as four rectus and two oblique muscles. However, their description and potential associations with species behavior are limited. The objective was to characterize extraocular muscles in four Myliobatoidei rays from diverse habitats with divergent behaviors.

Non-Bragg-gap solitons in one-dimensional Kerr-metamaterial Fibonacci heterostructures.

A detailed study of non-Bragg-gap solitons in one-dimensional Kerr-metamaterial quasiperiodic Fibonacci heterostructures is performed. The transmission coefficient is numerically obtained by combining the transfer-matrix formalism in the metamaterial layers with a numerical solution of the nonlinear differential equation in the Kerr slabs, and by considering the loss effects in the metamaterial slabs. A switching from states of no transparency in the linear regime to high-transparency states in the nonlinear regime is observed for both zero-order and plasmon-polariton gaps.

Metric-signature topological transitions in dispersive metamaterials.

The metric signature topological transitions associated with the propagation of electromagnetic waves in a dispersive metamaterial with frequency-dependent and anisotropic dielectric and magnetic responses are examined in the present work. The components of the reciprocal-space metric tensor depend upon both the electric permittivity and magnetic permeability of the metamaterial, which are taken as Drude-like dispersive models. A thorough study of the frequency dependence of the metric tensor is presented which leads to the possibility of topological transitions of the isofrequency surface determining the wave dynamics inside the medium, to a diverging photonic density of states at some range of frequencies, and to the existence of large wave vectors' modes propagating through the metamaterial.

Comparison of explosive force between young and elderly women: evidence of an earlier decline from explosive force.

The aging process causes many changes in muscle strength, and analysis of explosive force from handgrip strength seems to be useful and promising in studying the aging musculoskeletal system. Therefore, the purpose of this study was to investigate if explosive force parameters [rate of force development (RFD) and contractile impulse (CI) over the time interval of 0-200 ms from the onset of contraction] during handgrip efforts decline differently than maximum handgrip strength with increasing age. Twenty healthy young women (20-27 years) and 65 healthy elderly women, assigned into three age groups (50-64, 65-74, and 75-86 years), participated in this study.

Bulk plasmon polariton-gap soliton-induced transparency in one-dimensional Kerr-metamaterial superlattices.

We have performed a theoretical study of various arrangements of one-dimensional heterostructures composed by bilayers made of nondispersive (A)/dispersive linear (B) materials and illuminated by an obliquely incident electromagnetic wave, which are shown to exhibit a robust bulk-like plasmon-polariton gap for frequencies below the plasma frequency. The origin of this gap stems from the coupling between photonic and plasmonic modes that may be of a magnetic (electric) origin in a transversal electric (traversal magnetic) configuration yielding a plasmon-polariton mode. By substituting the nondispersive linear layer by a nonlinear Kerr layer, we have found that, for frequencies close to the edge of the plasmon-polariton gap, the transmission of a finite superlattice presents a multistable behavior and it switches from very low values to the maximum transparency at particular values of the incident power.

Cone-like graphene nanostructures: electronic and optical properties.

: A theoretical study of electronic and optical properties of graphene nanodisks and nanocones is presented within the framework of a tight-binding scheme. The electronic densities of states and absorption coefficients are calculated for such structures with different sizes and topologies. A discrete position approximation is used to describe the electronic states taking into account the effect of the overlap integral to first order.

Omnidirectional suppression of Anderson localization of light in disordered one-dimensional photonic superlattices.

The omnidirectional suppression of Anderson localization of light in a disordered one-dimensional normal-metamaterial photonic superlattice is thoroughly investigated. Analytical conditions relating to the electric-permittivity and magnetic-permeability responses of each slab of the heterostructure are established for the omnidirectional divergence of the localization length of the normal-metamaterial superlattice. The robustness of such conditions with respect to the degree of disorder of the superlattice is also analyzed.

Antinociceptive and anti-inflammatory effects of the monoterpene α,β-epoxy-carvone in mice.

α,β-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects.

Field profiles of bulk plasmon polariton modes in layered systems containing a metamaterial.

Electric and magnetic fields in a one-dimensional layered system that alternates air and a metamaterial are investigated. Special attention is devoted to frequencies of electric and magnetic bulk plasmons. It is shown that plasmon polaritons nearby such frequencies display field profiles concentrated in the metamaterial, where the field component parallel to the stacking direction is essentially uniform and dominates the perpendicular one.