Behavioral Profiling in Zebrafish Identifies Insecticide-Related Compounds.

Pesticides, including insecticides, are indispensable for large-scale agriculture. Modulating chloride ion channels has proven highly successful as a mode of action (MoA) for insect management. Identifying new ligands for these channels affords opportunities for the potential development of new insecticide products.

The Cumulative Burden of Social Risk Factors and 10-Year Change in Quality of Life.

Background: Social risk factors are linked to adverse health outcomes, but their total impact on long-term quality of life is obscure. We hypothesized that a higher burden of social risk factors is associated with greater decline in quality of life over 10 years.

Methods: We examined associations between social risk factors count and decline >5 points in (i) physical component summary, and (ii) mental component summary scores from the Short Form-12 among Black and White participants in the Reasons for Geographic and Racial Differences in Stroke study (n = 14 401).

Reflection Measurement of the Scattering Mean Free Path at the Onset of Multiple Scattering.

Multiple scattering of waves presents challenges for imaging complex media but offers potential for their characterization. Its onset is actually governed by the scattering mean free path ℓ_{s} that provides crucial information on the medium microarchitecture. Here, we introduce a reflection matrix method designed to estimate this parameter from the time decay of the single scattering rate.

Editors and Journals: Part III-" (Who Is In Charge)?".

Judging whether an editor is good at the job is essential; however, this task may be difficult or even impossible. Several factors are involved, many of which are beyond the control of an editor. We examined some of such situations, which are as follows: (1) Reviewer's abuse of privileged information, in which a reviewer or an associate, who is likely to be a competitor, directs members of their laboratory to rapidly replicate the data and submit the resulting paper in the same or another journal while delaying publication of the submitted paper; (2) defective micromanagement by a stakeholder or owner, such as failure to order paper for the publication of a journal; (3) penny-wise dollar-foolish mismanagement by the owner, such as limiting the figures allowed to an absurdly low number in a dermatology journal (we have a visual specialty); (4) factional abuse, such as when members of a society use a gimmick to exercise outsized influence to effect a change in journal's content, and (5) " (who is in charge)?," in which changes in the governance of an ownership society or publisher affect quality of the journal.

Mentorship Interventions in Postgraduate Medical and STEM Settings: A Scoping Review.

Background: Mentorship is critical to success in postgraduate science, technology, engineering, math, and medicine (STEMM) settings. As such, the purpose of this study is to comprehensively explore the state of mentorship interventions in postgraduate STEMM settings to identify novel practices and future research directions. The selection criteria for reviewed articles included: 1) published between 2002 and 2022, 2) peer-reviewed, 3) in English, 4) postgraduate mentees, 5) a program where mentorship is a significant, explicit focus, and 6) a description of mentee outcomes related to the mentorship intervention.

Self-Trephination in Cranial Excoriation Disorder.

Background And Importance: Trephination is a procedure in which a small hole is made in the skull. Rare cases of self-trephination by individuals seeking medical benefit have been reported. Excoriation disorder is a compulsive skin-picking condition in which an individual self-inflicts cutaneous lesions.

From endometrium to fingernail bed: histological evaluation of a rare cutaneous metastasis.

In the dermatological spectrum of oncologic manifestations, cutaneous metastases from endometrial carcinoma stand as a rarity, given the tumour's predilection for neighbouring uterine regions. We present an exceptional case of a patient in her mid-50s, whereby an endometrial carcinoma, defying conventional pathways, manifested on the skin and nail of her distal fourth finger, an unusual site for cutaneous metastases, with a specific histology of the primary cancer.

Ending "domestic helicopter research".

"Helicopter research" refers to a practice where researchers from wealthier countries conduct studies in lower-income countries with little involvement of local researchers or community members. This practice also occurs domestically. In this Commentary, we outline strategies to curb domestic helicopter research and to foster equity-centered collaborations.

Unlocking the power of virtual networking for early-career researchers.

Many successful researchers in the biomedical sciences have benefitted from mentors and networks earlier in their career. However, early-career researchers from minoritized and underrepresented groups do not have the same access to potential mentors and networks as many of their peers. In this article we describe how 'cold emails' and social media platforms - notably Twitter/X and LinkedIn - can be used to build virtual networks, and stress the need to invest in maintaining networks once they have been established.

Application of transcritical CO heat pumps to boiler replacement in low impact refurbishment projects.

80% of current UK housing stock is expected to still be in use in 2050. Difficult, intrusive and expensive, refurbishment measures are required to achieve the level of insulation required for current low temperature heat pumps. Transcritical CO heat pumps can achieve higher efficiencies, with higher output temperatures, than current, Carnot limited, synthetic gas heat pumps, with less environmental impact.

Revive the Dennie-Morgan Fold: A Forgotten Sign of Atopic Dermatitis in Children.

In 1980, Hanifin and Rajka (1) proposed major and minor diagnostic criteria for atopic dermatitis (AD). Major associations included pruritus, dry skin, and history of atopy. One minor feature included Dennie-Morgan Folds (DMFs), which manifest as secondary creases in the skin underneath the inferior eyelid, usually found in infants (2).

Artificial intelligence and the scientific method: How to cope with a complete oxymoron.

Artificial intelligence (AI) can be a powerful tool for data analysis, but it can also mislead investigators, due in part to a fundamental difference between classic data analysis and data analysis using AI. A more or less limited data set is analyzed in classic data analysis, and a hypothesis is generated. That hypothesis is then tested using a separate data set, and the data are examined again.

Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress.

To address the overuse of antimicrobials in poultry production, new functional feed ingredients, i.e. ingredients with benefits beyond meeting basic nutritional requirements, can play a crucial role thanks to their prophylactic effects.

How to cope with potential malfeasance using artificial intelligence: Call to action.

Just as fire and electricity can be, and in many ways are, of great benefit to humanity, and as the contributions elsewhere in this issue of Clinics in Dermatology have shown, artificial intelligence (AI) can be used for the ill and help in medicine. We offer several suggestions to counter some of the more egregious and obvious ones: AI-generated material that purports to be caused by humans and AI-generated material that purports to show actual people doing things that these people would not normally do. Both suggestions rely on methods already in existence to ensure public safety.

A History of Artificial Intelligence.

The development of the computer and what is now known as artificial intelligence (AI) has evolved over more than two centuries in a long series of steps. The date of the invention of the first computer is estimated at 1822, when Charles Babbage (1791-1871) developed his first design of a working computer on paper, based mainly on a Jacquard loom. He worked on his project together with Augusta Ada King, Countess Lovelace (née Byron) (Ada Lovelace) (1815-1852), whom he called the "Sorceress of Numbers.