Variations of lipid profile in animals caused by adenosine analogs: N6 (amido-3-propyl) adenosine hydrochloride and (carboxamido-3-propylamino)-6-(triproprionyl) 2',3',5'beta (D-ribosyl)-9-purine.

N6-substituted adenosine analogues are powerful inhibitors of lipolysis in the adipose tissues of animals and humans, because of their agonist effect on A1 purine receptors. Using a model of hypertriglyceridemia provoked by intravenous injection of Triton WR 1339, we observed that Agr 529 [N6(amido-3-propyl)adenosine hydrochloride] at 2 mg.kg-1 intravenous in rabbits, and intraperitoneally and orally in rats led to a return of the levels of circulating triglycerides to normal values.

[Continuous monitoring of temperature in anesthesia and intensive care].

Continuous surveillance of both regional and general temperatures is of great interest in anaesthesia and intensive care. After a brief review of temperature regulation and the value of temperature control, the authors suggest a simple and reliable method of surveillance. This uses Chromel/Alumel thermocouples connected to a central device used to store the information.

[Use of the Cerebral Function Monitor in the study of physiological sleep].

After a brief description of the different phases of physiological sleep, the reasons for employing a new appatus, the Monitor of Cerebral Function, are discussed. This instrument, the first designed for continual monitoring of cerebral activity may be employed in neurophysiology. The results obtained are presented, i.

[Cerebral Function Monitor (CFM) and electroencephalography (EEG). Experimental study].

This work is an attempt to connect the electro-encephalogram (EEG) and monitor of cerebral function (MCF) recordings during the experimental stimulation of the rabbit brain whether this is in the from of direct central stimulation, by stereotaxic location, or in the form of indirect stimulation via a peripheral nerve. These stimulations, performed under alfadione anaesthesia or under the neuroleptanalgesic sedative effect of chlorprothixine, are compared for every animal with the results of the control stimulations. The cardiovascular responses are recorded simultaneously.

[The Cerebral Function Monitor. Description, functioning and interpretation principles].

The Monitor of Cerebral Function enables continuous monitoring of the cerebral electrical activity and this over long periods due to the slow recording speeds. The cerebral electrical signals picked up by the electrodes attached to the scalp are registered in the form of a curve which fluctuates to a greater or lesser extent depending on the recording speed. The examination of the height of the curve with respect to zero and its amplitude indicates the voltage of the cerebral activity and yields information regarding polymorphism.

A study of eye movement for assessing recovery from anaesthesia.

A test for assessing recovery from general anaesthesia is proposed, using electro-oculographic (e.o.g.

[Monitoring the integrity of saccadic eye movements as a test of post-anaesthetic recovery (author's transl)].

After reviewing various tests of consciousness which can be used during the post-anaesthetic period, the authors chose to analyse the involvement of the visual receptor during different stages between sleep and complete recovery of consciousness, by an electro-oculographic (EOG) method, providing recordings of the displacement of the optical axis. In states of full consciousness the eye explores a static flat surface in saccades separated by pauses. During sleep caused by anaesthesia or by other types of drugs, the integrity of the eye positioning movements by saccades is impaired, and the EOG shows a sinusoidal recording (smooth movements).

[Neuroplegia in cranial and cranio-thoracic injuries].

During severe head injuries, the reaction to the cerebral lesion is intense and characterised by a disturbance which is automatic, vasomotor and endocrine. Associated with general ventilatory and nutritional resuscitation, neuroplegia occupies in this pathology, aplace of choice. Cranio-thoracic traumas raise more complex problems owing to different ventilatory requirements, depending on whether the lesion is of the brain or thorax.

[Neuroplegia: results of an interdisciplinary approach to its physiopathology].

Neuroplegia was born from a physiopathological study of states of shock and research on inhibition of the autonomic reaction to aggression. Over the last 25 years, the experimental facts have become accumulated in favour of the first theory of H. Laborit, i.

[Electromyography and AH/8165 in man].

This article concerns the electromyographical study of a synthetic curare derived from Azobis Arylimidazo (1-2a) Pyridinium (AH/8165) with a simultaneous recording of the spontaneous diaphragmatic activity and "testing" of the neuro-muscular transmission at the level of a peripheral muscle. This study shows that AH/8165 is a powerful non-depolirizing curarimimetic drug that quickly induces a neuro-muscular block at the level of the diaphragm and the peripheric muscles that can be reversed by anticholinesterasic drugs. Its reaction time is short (about 1 mn).

[Corticoids and shock].

After recalling the major role of catecholamines in the genesis of irreversible shock, the anti-shock action of glucocorticosteroids, owing to properties which are "alpha-blocking" , is discussed in this work. The works of LILLEHEI on the effectiveness of corticosteroids in different types of shock are summarized and discussed, as well as numerous works which have followed and a synopsis of which, done in 1967 in the "Annales de l'Anesthésiologie Francaise", is presented. Since then, following new experimental facts, whereas numerous contradictions have appeared in the clinical and experimental realms, the possible mechanisms of action of corticosteroids in shock are looked at, by emphasizing the relationships between corticosteroids and SHWARTZMAN's phenomenon, in particular.

[Iskedyl and general anesthesia. Measurement of the systolic ejection volume and peripheral resistance using the arterial pressure curves].

ISKEDYL (PF 50), which is sold as a vasoregulator of cerebral irrigation, consists of a mixture of dihydroergocristine and raubasine. This work aims at determining possible interactions between this product and certain drugs used in anesthesia from the cardiovascular point of view. ISKEDYL does not seem to be a contraindication to anesthesia of the "neuroleptic" type, when injected in pre-, per- or post-operative period.