Publications by authors named "L-S Ro"
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.
Cell
December 2021
Article Synopsis
- Colorectal cancers develop from polyps, and this study creates a detailed single-cell atlas of conventional adenomas and serrated polyps to understand their origins and characteristics.
- The research reveals that adenomas stem from the growth of stem cells driven by WNT signaling, while serrated polyps emerge from differentiated cells undergoing gastric metaplasia, which leads to a damaged immune environment.
- The findings highlight how changes in tumor cell differentiation affect immune responses and contribute to cancer progression, offering valuable insights for more targeted monitoring and prevention strategies for colorectal cancer.
Background: Family genetic testing of patients newly diagnosed with a rare genetic disease can improve early diagnosis of family members, allowing patients to receive disease-specific therapies when available. Fabry disease, an X-linked lysosomal storage disorder caused by pathogenic variants in GLA, can lead to end-stage renal disease, cardiac arrhythmias, and stroke. Diagnostic delays are common due to the rarity of the disease and non-specificity of early symptoms.
View Article and Find Full Text PDF"Real-world" data on the nationwide epidemiology and treatment patterns of multiple sclerosis (MS) is very scarce in Asia. This study is aim to evaluate the 10-years trends in epidemiology and treatment patterns of MS with Taiwan's National Health Insurance Database (NHIRD). Patients aged 20 years or older and were newly diagnosed with MS between 2007 and 2016 were identified.
View Article and Find Full Text PDFObjective: To test the hypothesis that transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial.
Methods: Outcomes were based on the Clinical Rating Scale for Tremor, including hand combined tremor-motor (scale of 0-32), functional disability (scale of 0-32), and postural tremor (scale of 0-4) scores, and total scores from the Quality of Life in Essential Tremor Questionnaire (scale of 0-100). Scores at 36 months were compared with baseline and at 6 months after treatment to assess for efficacy and durability.