Tailoring Robust 2D Nanochannels by Radical Polymerization for Efficient Molecular Sieving.

Two-dimensional (2D) nanochannels have demonstrated outstanding performance for sieving specific molecules or ions, owing to their uniform molecular channel sizes and interlayer physical/chemical properties. However, controllably tuning nanochannel spaces with specific sizes and simultaneously achieving high mechanical strength remain the main challenges. In this work, the inter-sheet gallery d-spacing of graphene oxide (GO) membrane is successfully tailored with high mechanical strength via a general radical-induced polymerization strategy.

Post-irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated With Proton Therapy.

Objective: Post-irradiation sinonasal mucosa disease (SMD) is observed in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy (RT), leading to a detrimental impact on quality of life. This study aimed to assess the incidence, severity, and regression of the post-irradiation SMD among patients with NPC treated with proton therapy.

Methods: NPC patients treated with proton therapy were retrospectively enrolled.

Self-cleaning micro/nano graded porous groove structure fiber membranes by coaxial spinning for purification of dye wastewater.

Adjusting the structure of the membrane and improving its performance proved to be an effective technique for accomplishing efficient dye wastewater purification. Water erosion of polyvinylpyrrolidone (PVP) core in polyacrylonitrile (PAN) nanofiber membrane modified with UiO-66-NH was successfully achieved, in this study, using coaxial electrospinning, and ZIF-8 with excellent performance was further epitaxy-grown in situ. Two differently shaped and positively charged MOFs confer strong adsorption capacity (adsorption capacity >2042 mg/g) on cationic dyes.

A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer.

Immune exclusion inhibits anti-tumor immunity and response to immunotherapy, but its mechanisms remain poorly defined. Here, we demonstrate that Trophoblast Cell-Surface Antigen 2 (TROP2), a key target of emerging anti-cancer Antibody Drug Conjugates (ADCs), controls barrier-mediated immune exclusion in Triple-Negative Breast Cancer (TNBC) through Claudin 7 association and tight junction regulation. TROP2 expression is inversely correlated with T cell infiltration and strongly associated with outcomes in TNBC.

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.

Editing the +58 region of the BCL11A erythroid enhancer has shown promise in treating β-globin disorders. To address variations in fetal hemoglobin (HbF) response, we investigated editing both +58 and +55 enhancers. Rhesus macaques transplanted with edited hematopoietic stem/progenitor cells (HSPCs) following busulfan conditioning exhibited durable, high-level (∼90%) editing frequencies post transplantation with sustained HbF reactivation over 4 years, without hematological perturbations.

Middle Meningeal Artery Embolization for Nonacute Subdural Hematoma.

Background: The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.

Methods: We performed a multicenter, open-label, randomized trial in China, involving patients with symptomatic nonacute subdural hematoma with mass effect. Patients were assigned to undergo burr-hole drainage or receive nonsurgical treatment at the surgeon's discretion, and patients in each group were then randomly assigned, in a 1:1 ratio, to undergo middle meningeal artery embolization with liquid embolic material or to receive usual care.

Non-serious adverse events in patients with ulcerative colitis receiving etrasimod: an analysis of the phase II OASIS and phase III ELEVATE UC 52 and ELEVATE UC 12 clinical trials.

Background: Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). It is known that non-serious treatment-emergent adverse events (TEAEs) may not lead to UC drug discontinuation but can affect treatment tolerability.

Objectives: This post hoc analysis evaluated the incidence of specific, common, non-serious TEAEs reported in the etrasimod UC clinical programme and the characteristics of affected patients.

A capillary effect-inspired sponge-structured carboxymethyl cellulose aerogel layer-modified membrane for efficient separation of dye/salt under ultra-low-pressure.

In the field of wastewater treatment, the efficient separation of dyes/salts and the high-pressure drive easily results in concentration polarization and membrane contamination. In this study, inspired by the capillary effect of natural sponge structure, an aerogel layer with a bionic three-dimensional mesh porous sponge structure was designed to construct an ultra-low-pressure membrane. With the assistance of tannic acid, the carboxymethyl cellulose (CMC) aerogel layer were constructed on the surface of polyvinylidene fluoride (PVDF) membrane using the layer-by-layer cross-linking and freeze-drying methods.

Individually addressed entangling gates in a two-dimensional ion crystal.

Two-dimensional (2D) ion crystals may represent a promising path to scale up qubit numbers for ion trap quantum information processing. However, to realize universal quantum computing in this system, individually addressed high-fidelity two-qubit entangling gates still remain challenging due to the inevitable micromotion of ions in a 2D crystal as well as the technical difficulty in 2D addressing. Here we demonstrate two-qubit entangling gates between any ion pairs in a 2D crystal of four ions.

Preparation of hydrophilic PVDF membranes through in situ assembly of phytate-polyethyleneimine-Fe for efficient separation of herbal volatile oil from oily water.

In the realm of oil-water separation technologies, membrane-based separation emerges as an efficacious approach. Nevertheless, crafting a hydrophilic membrane capable of effectively segregating herbal volatile oil remains a formidable challenge. Our study introduces a facile in situ assembly strategy for fabricating a double-crosslinked composite coating comprising phytate (PA)-polyethyleneimine (PEI) polyelectrolyte complexes and PA-Fe⁺ assemblies.

A comprehensive evaluation of the endocrine-disrupting effects of emerging organophosphate esters.

The ubiquitous presence of organophosphate esters (OPEs) in the environment has prompted growing concerns about their potential health risks, particularly their endocrine-disrupting effects. This study comprehensively evaluated the endocrine-disrupting properties of six emerging OPEs: five aryl-OPEs (2-ethylhexyl diphenyl phosphate (EHDPP), tris (2-biphenylyl) phosphate (TBPP), resorcinol bis (diphenyl phosphate) (RDP), 4-hydroxyphenyl diphenyl phosphate (para-OH-TPHP), and 3-hydroxyphenyl diphenyl phosphate (meta-OH-TPHP) and one alkyl-OPE, triallyl phosphate (TAP). Our findings revealed that all tested aryl-OPEs exhibited antagonistic effects on one or more hormone receptors.

Bubble Drainage Assisted Fabrication of Polyamide Membranes with Crater-like Structures for Efficient Desalination.

Bubble drainage (BD) occurs in various natural phenomena and industrial activities, in which bubbles rise toward the water surface and create a progressively thinned two-sided liquid film, called a lamella. Surfactant, as an important regulator in the BD process, not only assembles on both sides of the lamellae, generating a configuration of lamellae sandwiched by monolayers of surfactants (lamellae/MS), but also induces interfacial deformation by lowering interfacial tension. Herein, we developed a strategy of BD assisted interfacial polymerization for the fabrication of polyamide (PA) membranes.

Supramolecular-coordinated nanofiltration membranes with quaternary-ammonium Cyclen for efficient lithium extraction from high magnesium/lithium ratio brine.

Ion-selective membranes (ISM) with sub-nanosized pore channels hold significant potential for applications in saline wastewater treatment and resource recovery. Herein, novel synergistic ion channels featuring bi-periodic structures were constructed through the coordination of functional Cyclen (quaternary_1,4,7,10-tetraazacyclododecane, Q_Cyclen) and Cu-m-Phenylenediamine (Cu-MPD) to develop supramolecular membranes for lithium extraction. The exterior quaternary ammonium-rich sites exhibit a significant Donnan exclusion effect, resulting in tremendous mono/divalent (Li/Mg) ion selectivity; while the interior regular-confined channels of Cyclen yield a fast vehicular pathway, facilitating water molecules and Li ion-selective transport.

A heterogeneous polyurethane hybrid foam with enhanced demulsification and dynamic oil cleaning for continuous emulsion separation.

Here, a top-down strategy was presented to fabricate a heterogeneous polyurethane hybrid foam with independent oil-absorbing frameworks and uninterrupted water transport channels for continuous emulsion separation. A commercial polyurethane foam (PUF) was hydrophobically modified to develop oil-absorbing frameworks (HPUF). Superhydrophilic carbon nanotubes/cellulose nanofibers (CNTs/CNFs) aerogels were assembled in the voids of the HPUF to establish independent water transport channels, forming a heterogeneous polyurethane hybrid foam (CHPUF).

Overloading And unpacKing (OAK) - droplet-based combinatorial indexing for ultra-high throughput single-cell multiomic profiling.

Multiomic profiling of single cells by sequencing is a powerful technique for investigating cellular diversity. Existing droplet-based microfluidic methods produce many cell-free droplets, underutilizing bead barcodes and reagents. Combinatorial indexing on microplates is more efficient for barcoding but labor-intensive.

Incorporation of Graphene Oxide Quantum Dots in Gradient Layers of Polyethersulphone Nanofiltration Membranes for Nitrate Rejection from Aqueous Solution.

Graphene oxide quantum dots (GOQDs) have been widely used to prepare nanofiltration membranes due to the merits of excellent dispersity, ultrasmall size, and unique properties related to graphene. In this study, we first prepared the polyethersulphone-based nanofiltration (PES-NF) membrane via an interfacial polymerization process using a piperazine and -phenylenediamine mixed solution as the aqueous phase. Then GOQDs were incorporated into the top-down gradient structured layers (i.

Real-world impact of emicizumab and immunosuppression on acquired hemophilia A: a multicenter US cohort.

Acquired hemophilia A (AHA) is an autoimmune bleeding disorder that is caused by factor VIII (FVIII) autoantibodies with high morbidity and mortality due to bleeding and complications from immunosuppression (IST). To address the real-world implications of the FVIII mimetic antibody, emicizumab, and the role of IST, we retrospectively collected de-identified data on 62 patients with AHA who were treated off-label with emicizumab for a median of 10 weeks at 12 US-based hemophilia treatment centers. Most patients (95.

Molecular landscape of ERBB2 alterations in 3000 advanced NSCLC patients.

ERBB2 (HER2) represents a newly recognized actionable oncogenic driver in non-small cell lung cancer (NSCLC), with approved targeted therapy available. Understanding the landscape of ERBB2 alterations and co-occurring mutations is essential for guiding treatment decisions. We conducted an analysis involving 3000 NSCLC patients with all types of ERBB2 alterations, drawn from two extensive retrospective cohorts: 1281 from Geneplus (Chinese) and 1719 from Guardant360 (the United States, US).

Computer-aided drug design to generate a unique antibiotic family.

The World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention. Here, computer-aided drug design is used to develop a structurally unique antibiotic family targeting holo-acyl carrier protein synthase (AcpS).

Degradable polyvinyl alcohol/chitosan@carnauba wax superhydrophobic composite membrane for water-in-oil emulsion separation and heavy metal adsorption.

At present, many oil-water separation membranes are being developed to purify oily wastewater. However, oily wastewater often contains heavy metal, which are often difficult to dispose during separation. Furthermore, most of the oil-water separation membranes cannot be degraded after scrap, producing pollution to environment.