Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner.

Housing animals in enriched environments (EEs) results in improved learning and memory (L&M) performance. While increased intrinsic cellular excitability in the hippocampal neurons might underlie the environmental enrichment-dependent L&M enhancement, literature in respect to this remains scarce and controversial. In this study, we explore whether intrinsic cellular excitability in hippocampal CA1 pyramidal cells is modulated differently, depending on housing duration and anatomical location of cells.