[Experimental aspects of pathogenesis and prophylaxis of gastric stress ulcers (author's transl)].

The prophylactic efficacy of various treatments was examined in porcine haemorrhagic shock [13] by measuring total and regional gastric blood flow with radioactive Microspheres. All 24 animals of the control-group (no treatment) developed extensive haemorrhagic lesions of the stomach. Total gastric blood flow fell almost by 90% during shock.

[Experiences with the hemorrhagic shock in immature pigs (author's transl)].

In 74 immature pigs a hemorrhagic shock (3 hrs duration: mean arterial pressure 40 mm Hg) was established (NORTON 1972). Following this systemic stress all animals developed stress-lesions of stomach and duodenum. In comparison to other stress-models porcine hemorrhagic shock seems to be qualified to study pathogenesis, prophylaxis and therapy of gastric stress-lesions: Pigs correspond best to humans in their gastro-intestinal physiology, hypotension simulates one of the most important surgical causes of stress complications and stress-lesion produced by this model have a marked similarity to those of humans.

[Sympathectomy of the stomach: an effective preventive measure in stress-induced gastric mucosa lesions in swine].

15 mini-pigs were bled to a mean aortic blood-pressure of 40 mm Hg, which was sustained for 3 hours. 2 groups were studied: Control-Group: Shock alone without splanchnicectomy (n = 8); Test-Group: Shock after splanchnicectomy 14 days previously (n = 7). In all animals a stimulated gastric secretion test was performed 3 days before and 8 days after this operation.

[The effect of antacids on stress-induced lesions of the gastric mucosa in the piglet (author's transl)].

After administration of antacids, gastric stress lesions due to hemorrhagic shock appear in the pig stomach quicker and more markedly than in animals which have been similarly treated with an indifferent substance or not at all. However, once treated, the administration of antacids seems to favor the healing of mucosal lesions after the end of the stress. At the same time it was observed that after administration of antacids in hemorrhagic shock, the serum gastrin level rises and does not remain constant, as in the control group.

[Effect of truncal vagotomy on the occurence of gastric mucosal lesions induced by hemorrhagic shock in piglets (author's transl)].

3 groups of total 37 mini-pigs have been bled to a mean aortic blood pressure of 40 mm Hg for three hours (Norton et al., 1972): Group I: hemorrhagic shock along (n = 15) Group II: right thoracotomy prior to shock without vagotomy (n = 4) Group III: right thoracotomy prior to shock with truncal vagotomy right above diaphragm (n = 15) 3 animals died during shock. All others showed severe mucosal hyperaemia and hemorrhage after shock, which intensified in animals without vagotomy during 8-24 hours.