Publications by authors named "L van der Molen"
Aging of the brain vasculature plays a key role in the development of neurovascular and neurodegenerative diseases, thereby contributing to cognitive impairment. Among other factors, DNA damage strongly promotes cellular aging, however, the role of genomic instability in brain endothelial cells (EC) and its potential effect on brain homeostasis is still largely unclear. We here investigated how endothelial aging impacts blood-brain barrier (BBB) function by using excision repair cross complementation group 1 (ERCC1)-deficient human brain ECs and an EC-specific Ercc1 knock out (EC-KO) mouse model.
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- This study explored the long-term effects of using a device (SEA2.0) for swallowing rehabilitation in individuals who have had their larynx removed (laryngectomized).
- Seventeen participants were evaluated six months after initial training, revealing that while some aspects of swallowing improved from the start of the study, there was a decline in swallowing capacity compared to an earlier assessment after a rest period.
- Overall, although the benefits of rehabilitation were still noticeable long-term, ongoing exercise may be necessary to maintain these improvements, indicating a need for further research on the best practices for sustaining swallowing function.
Article Synopsis
- - The review investigates the role of pharyngeal high-resolution manometry (HRM/HRIM) in assessing swallowing issues in patients with head and neck cancer, highlighting its clinical relevance and usefulness.
- - Eight studies were included, showing that head and neck cancer patients with swallowing difficulties have lower pressure in the pharynx and upper esophagus compared to healthy individuals, which may be linked to their cancer and treatment.
- - While HRM/HRIM is not commonly used in clinical practice for these patients, the review suggests it could improve diagnosis and management of swallowing problems, potentially leading to better treatment outcomes.
The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma.
Head Neck
January 2025
Introduction: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar skeletal muscle index (LSMI) may experience higher serum peak dosages of cisplatin. This study investigated whether pre-treatment low LSMI is associated with increased SNHL upon cisplatin-based CRT.
View Article and Find Full Text PDFPurpose: To explore current practice variation and degree of consensus among international clinical experts regarding the diagnosis, classification, measurement, and treatment of head and neck lymphedema (HNL) after head and neck cancer treatment.
Materials And Methods: We conducted an online Delphi study. Eligible participants were clinical researchers who had (co)authored at least one publication on HNL and healthcare professionals who had treated at least five patients with HNL the last two years.