Publications by authors named "L van de Schoot"
Dose reduction (DR) of first-generation biologics for plaque psoriasis (TNF-alpha inhibitors (i) and interleukin (IL)-12/23i) has been described in a previous scoping review. The literature on the DR of the newest generation of biologics (IL-17/23i) was scarce. The current review provides a literature update on the previous scoping review on the DR of all biologics, including the newest generation, with a focus on the uptake and implementation of DR in practice.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the implementation of dose reduction (DR) for biologic treatments in psoriasis patients across three hospitals over six months.
- It found that while the implementation strategy was generally followed, not all healthcare providers utilized the tools provided, indicating areas for improvement.
- Successful implementation of DR was linked to better patient support, guideline integration, and efficient electronic health systems, which helped 50% of eligible patients start DR.
Dose reduction of biologics for psoriasis could contribute to more efficient use of these expensive medicines. Evidence on opinions of patients with psoriasis regarding dose reduction is sparse. The objective of this study was therefore to explore patients' perspectives towards dose reduction of biologics for psoriasis.
View Article and Find Full Text PDFArticle Synopsis
- This study addresses the lack of guidelines for biologic dose reduction in psoriasis treatment, aiming for clear criteria to support consistent practices among clinicians.
- An online voting process involving Dutch dermatologists led to consensus on 15 recommendations for dose reduction eligibility, criteria for discontinuation, and specific dosing schedules for commonly used biologics.
- The final recommendations and an implementation algorithm are intended to help doctors make informed decisions about reducing biologic treatment in stable psoriasis patients, improving care consistency for their patients.