Publications by authors named "L van Ruijven"
Article Synopsis
- Spondyloarthritis (SpA) involves abnormal bone growth and inflammation, and current treatments mainly address inflammation but not bone growth; this study focuses on how specific blood vessels (type H) might play a role in SpA pathology.
- Researchers studied tmTNF-Tg mice, which mimic SpA features, and found increases in type H vessels and bone-forming cells before clinical symptoms appeared, indicating early changes in the disease.
- The findings suggest that type H vessels contribute to pathologic bone growth in SpA and highlight potential new treatment strategies targeting these vessels in the disease's progression.
Purpose: To assess the effect of radiation therapy on osteocyte apoptosis, osteocyte death, and bone marrow adipocytes in the human mandible and its contribution to the pathophysiology of radiation damage to the mandibular bone.
Methods And Materials: Mandibular cancellous bone biopsies were taken from irradiated patients and nonirradiated controls. Immunohistochemical detection of cleaved caspase-3 was performed to visualize apoptotic osteocytes.
Objective: The aim of the present study was to assess mineralization and trabecular microarchitecture in atrophic edentulous mandibles and to identify regional differences and relations with the extent of resorption.
Methods: Cortical and trabecular bone volumes in anterior, premolar and molar regions of 10 edentulous cadaveric mandibles (5 males and 5 females; mean age ± SD: 85.4 ± 8.
Glucocorticoid (GC)-induced osteoporosis is a widespread health problem that is accompanied with increased fracture risk. Detrimental effects of anti-inflammatory GC therapy on bone have been ascribed to the excess in GC exposure, but it is unknown whether there is also a role for disruption of the endogenous GC rhythm that is inherent to GC therapy. To investigate this, we implanted female C57Bl/6J mice with slow-release corticosterone (CORT) pellets to blunt the rhythm in CORT levels without inducing hypercortisolism.
View Article and Find Full Text PDFBackground: Autologous bone grafts have been applied successfully to severely atrophied maxilla via a preimplant procedure. Differences in graft incorporation at the microscopic level can be the decisive factor in the choice between anterior iliac crest and calvarial bone.
Purpose: To compare conversion of anterior iliac crest bone and calvarial bone 4 months after grafting of the edentulous maxilla.