Publications by authors named "L van Hoe"
Background: Approximately one-half of the patients with angina and nonobstructive coronary artery disease (ANOCA) have evidence of coronary microvascular dysfunction (CMD).
Objectives: This study aims to characterize patients with ANOCA by measuring their minimal microvascular resistance and to examine the pattern of vascular remodeling associated with these measurements.
Methods: The authors prospectively included patients with ANOCA undergoing continuous thermodilution assessment.
Background: The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI.
View Article and Find Full Text PDFBackground: Two invasive methods are available to estimate microvascular resistance: bolus and continuous thermodilution. Comparative studies have revealed a lack of concordance between measurements of microvascular resistance obtained through these techniques.
Aims: This study aimed to examine the influence of vessel volume on bolus thermodilution measurements.
Article Synopsis
- Shock-induced endotheliopathy (SHINE) is a condition characterized by severe endothelial dysfunction due to extreme sympathetic activation during shock states, which can worsen organ perfusion despite aggressive resuscitation efforts.
- This study systematically reviewed literature from Jan 2011 to July 2023, focusing on how resuscitation can affect endothelial health in critically ill patients, while excluding animal studies and reviews.
- Out of 32 relevant studies analyzed, many identified biomarkers related to endothelial damage, but only a few comparable studies were suitable for a quantitative meta-analysis on specific markers like syndecan-1 and thrombomodulin, indicating significant variability in the results.
Article Synopsis
- The study aimed to evaluate the accuracy of a virtual stenting tool, the FFR Planner, which uses coronary CT angiography (CCTA) data to predict fractional flow reserve (FFR) after percutaneous coronary interventions (PCI) in patients with chronic coronary syndromes.
- It found that the FFR Planner showed good agreement with invasively measured post-PCI FFR across varying levels of CCTA image quality, with a mean difference of only 0.02 FFR units among different image quality scores.
- The findings suggest that the FFR Planner's accuracy is influenced by a higher nitrate dose, and its reliability across various image qualities may enhance clinical decision-making in coronary interventions.