[The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs].

Aim: To perform a chemoreactome modeling of the pharmacological central effects of 4 non-steroidal anti-inflammatory drugs (NSAIDs): dexketoprofen, ketoprofen, aceclofenac, lornoxicam.

Material And Methods: An analysis of the pharmacological spectrum of the central action of dexketoprofen, ketoprofen, aceclofenac and lornoxicam was based on the chemoinformatic approach, which compared drug-likeness properties with public and commercial software.

Results: The effectiveness of NSAIDs is related to the inhibition of cannabinoid receptors CB-1, the vanilloid receptor TRPV1, NMDA and AMPA receptors and of the GABA reuptake transporter, with dexketoprofen being the most effective inhibitor.

[Comparative studies of neurotrophic drugs based on brain hydrolysates].

The results of the analysis of comparative studies of neurotrophic drugs based on brain hydrolysates (BH) are presented. The most comprehensive comparative study of the BH drugs carried out by Zhang, et al. 2019 investigated the effects of four drugs (cognistar, cerebrolysate, cortexin, cerebrolysin) on a model of ischemic stroke in rats.

[An analysis of epidemiological indices of stroke based on the data of a regional population register from 2009 to 2012].

Objective: To study the dynamics of basic epidemiological sex- and age-related indices in the Russian Federation for 2009-2012. MATERIAL AND METHODS. The regions (administrative units, cities or city regions) with the population from 100 000 to 200 000 people were selected.

[Clinical efficacy and pharmacoeconomic characteristics of the neuroprotection with low doses of cortexin in the treatment of acute ischemic stroke].

Objective: To assess the efficacy of the cytoprotective neuropeptide cortexin in the complex treatment in acute and early rehabilitation stages of ischemic stroke (II).

Material And Methods: A multicenter prospective double-blind placebo-controlled trial has been carried out. Two hundreds and seventy-two patients with II have been enrolled in the trial.

[The dynamics of the morbidity rate of stroke in the Dagestan Republic].

Results of the first epidemiologic survey of cerebral stroke in the Dagestan Republic (DR) carried out in 2009--2010 are presented. Using a population register, we evaluated the dynamics of the morbidity rate of stroke and effectiveness of primary and secondary prevention of stroke. There were 7533 cases of stroke, including 4116 in 2009 and 3413 in 2010.