Compaction is the first morphogenetic movement of the eutherian mammals and involves a developmentally regulated adhesion process. Previous studies investigated cellular and mechanical aspects of compaction. During mouse and human compaction, cells spread onto each other as a result of a contractility-mediated increase in surface tension pulling at the edges of their cell-cell contacts.
View Article and Find Full Text PDFAt the early stage of tumor progression, fibroblasts are located at the outer edges of the tumor, forming an encasing layer around it. In this work, we have developed a 3D in vitro model where fibroblasts' layout resembles the structure seen in carcinoma in situ. We use a microfluidic encapsulation technology to co-culture fibroblasts and cancer cells within hollow, permeable, and elastic alginate shells.
View Article and Find Full Text PDFObservers adopt attentional control settings (ACSs) based on their goals that guide the capture of attention: Searched-for stimuli capture attention, and stimuli that are not searched for do not. While previous behavioural research indicates that observers can adopt long-term memory (LTM) ACSs (Giammarco et al. Visual Cognition, 24, 78-101, 2016), it seems surprising that representations in LTM could guide attention quickly enough to control attentional capture.
View Article and Find Full Text PDFCell fragmentation is commonly observed in human preimplantation embryos and is associated with poor prognosis during assisted reproductive technology (ART) procedures. However, the mechanisms leading to cell fragmentation remain largely unknown. Here, light sheet microscopy imaging of mouse embryos reveals that inefficient chromosome separation due to spindle defects, caused by dysfunctional molecular motors Myo1c or dynein, leads to fragmentation during mitosis.
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